Postdoctoral researcher on nuclear pore complexes M/F

Job Description

Missions

The selected candidate will join the team studying the signaling pathways responsible for the assembly of nuclear pore complexes during the cell cycle in healthy and diseased cells, in the Functional Genomics and Cancer Department at IGBMC. He/she will work under the direct supervision of team leader Izabela Sumara, in collaboration with other members of the lNCa program (PLBIO22-086).

Scientific program and tasks: Nuclear pore complexes (NPCs) are large protein assemblies embedded in the nuclear envelope (NE) that facilitate bidirectional transport between the nucleus and the cytoplasm. In addition, NPCs establish direct contacts with chromatin and contribute to gene regulation. Despite their important functions in the cell and their increase in cancer cells, it is still unclear how cancer cells manage to assemble more NPCs and whether they are dependent on this mechanism. Our preliminary results demonstrate the crucial role of UBAP2L in the assembly of nucleoporins (Nups) into NPCs and reduced growth of several cancer cell lines when this regulatory pathway is blocked.

The successful candidate will lead a research project aimed at studying the assembly mechanisms of nuclear pore complexes (NPCs) in cancer cells.

Activity

- The selected candidate will study the mechanisms of nuclear pore assembly in cancer cells.
- He/she will study the exact molecular mechanisms by which UBAP2L regulates NPC assembly in cancer cells by combining cell biology, advanced microscopy, and biochemical approaches.
- He/she will actively participate in communicating his/her results within the laboratory and the institute.
- He/she will study the molecular mechanisms involved in the assembly of nuclear pore complexes in cancer cells, with a particular focus on the role of the UBAP2L protein in the assembly of nucleoporins (Nups) and the formation of NPCs.
- He/she will implement experimental approaches combining cell biology, advanced microscopy, and biochemical methods to characterize the regulatory pathways controlling NPC assembly and their involvement in cancer cell proliferation.
- He/she will design, plan, and carry out experiments, analyze and interpret the data obtained, and contribute to the development of new experimental strategies within the framework of the project.
- He/she will participate in promoting and communicating scientific results, particularly during team meetings, institute seminars, and through the writing of scientific publications.
- He/she will contribute to the supervision and training of master's students involved in the project.
- II/He/she will participate in the team's collective scientific activities and collaborations with other members of the INCa program (PLBIO22-086).

Your Profil

Skills

- The successful candidate must hold a PhD in biology and have experience in molecular and cellular biology, cell culture, and microscopy.
- Scientific knowledge, scientific rigor, excellent organizational skills, and proficiency in English (level C1 of the European Framework).
- Dynamic and respectful personality, team spirit, and strong motivation.

Your Work Environment

The CNRS (National Center for Scientific Research), certified HR Excellence in Research, is one of the world's leading multidisciplinary public research organizations. The IGBMC (Institute of Genetics and Molecular and Cellular Biology), one of Europe's leading biomedical research centers, is a joint research unit associated with the CNRS, INSERM, and the University of Strasbourg.
The successful candidate will work at the IGBMC and benefit from an exceptional international scientific environment. The IGBMC has around 40 teams divided into four scientific departments and state-of-the-art technological platforms on site.
The direct scientific collaborator for the project funded by the INCa is Dr. Dominique Weil (IBPS, Paris). In addition, the team's research project on nuclear pores involves numerous national and international collaborators, including Bruno P. Klaholz, Ali Hamiche, Christelle Golzio, Lionel Pintard, Guillaume Chevreux, and Yannick Schwab.
The candidate will join Izabela Sumara's team at the IGBMC, which studies the signaling pathways responsible for the assembly of nuclear pore complexes during the cell cycle in healthy and diseased cells.

The successful candidate will have access to the CROUS restaurant.
The site can be reached by tram (line A, Campus Illkirch station) from Strasbourg train station or by car (parking available). Public transportation costs are partially covered.

Compensation and benefits

Compensation

From 3 071,50 to 3 501,51 based on experience

Annual leave and RTT

44 jours

Remote Working practice and compensation

Pratique et indemnisation du TT

Transport

Prise en charge à 75% du coût et forfait mobilité durable jusqu’à 300€

About the offer

About the CNRS

The CNRS is a major player in fundamental research on a global scale. The CNRS is the only French organization active in all scientific fields. Its unique position as a multi-specialist allows it to bring together different disciplines to address the most important challenges of the contemporary world, in connection with the actors of change.

CNRS

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