Postdoctoral Researcher (M/F) - Study of the Energy Landscape of RCPGs in Lipid Discs
New
- Researcher in FTC
- 15 months
- Doctorate
This offer is available in English version
This offer is open to people with a document recognizing their status as a disabled worker.
Offer at a glance
The Unit
Biochimie des protéines membranaires
Contract Type
Researcher in FTC
Working hHours
Full Time
Workplace
75005 PARIS 05
Contract Duration
15 months
Date of Hire
01/02/2027
Remuneration
Between €4,000 and €4,500 gross per month
Apply Application Deadline : 22 October 2026 23:59
Job Description
Missions
To design and carry out the production, purification, and biophysical characterization of GPCR receptors within lipid nanodisks. The goal is to propose a mechanistic model of how the physical properties of the membrane affect the energy landscape of GPCR receptors.
Activity
- Produce and purify membrane and lipoprotein receptors (heterologous expression in E. coli and SF9 cells)
- Characterize these proteins using biochemical, pharmacological, and biophysical techniques (NMR, cubic-phase crystallography)
- Disseminate the results through publications, oral presentations, and posters at national and international conferences.
Your Profil
Skills
- Knowledge of the biochemistry of membrane proteins
- Knowledge of the biochemistry of lipids
- Knowledge of the pharmacology of RCPGs
- Knowledge of NMR is a plus
- Ability to purify proteins using chromatography
- Ability to perform eukaryotic cell cultures
- Ability to handle membrane proteins in detergent solutions and reconstitute them into lipid nanodisks
- Ability to write in English
- Ability to provide scientific guidance to interns (Bachelor's to Master's level)
- Scientific rigor
- Reliability and traceability of results (data management, lab notebook)
- Independence and initiative in conducting experiments
- Ability to work as part of a team within a multidisciplinary unit
Your Work Environment
The project is part of the ANR “MECHANOACT-I” program under the scientific supervision of Laurent Catoire at UMR 7099 (BPM - Biochemistry of Membrane Proteins), directed by Martin Picard.
The project aims to elucidate the coupling mechanism between the mechanical properties of the lipid membrane and eukaryotic receptors.
Compensation and benefits
Compensation
Between €4,000 and €4,500 gross per month
Annual leave and RTT
44 jours
Remote Working practice and compensation
Pratique et indemnisation du TT
Transport
Prise en charge à 75% du coût et forfait mobilité durable jusqu’à 300€
About the offer
| Offer reference | UMR7099-CORLAR-003 |
|---|---|
| CN Section(s) / Research Area | Molecular and structural biology, biochemistry |
| Relevant experience | 1 to 4 years |
About the CNRS
The CNRS is a major player in fundamental research on a global scale. The CNRS is the only French organization active in all scientific fields. Its unique position as a multi-specialist allows it to bring together different disciplines to address the most important challenges of the contemporary world, in connection with the actors of change.
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