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Portail > Offres > Offre UMR7057-CARPHI-009 - Ingénieur d'étude (H/F) sur la mise en place d'un modèle d'animal de maladie inflammatoire digestive et évaluation d'une biothérapie à base vésicules extracellulaires

Study engineer (M/F) on the implementation of an animal model of digestive inflammatory disease and evaluation of a biotherapy based on extracellular vesicles.d'un modèle d'animal de maladie inflammatoire digestive et évaluation d'une biothérapie à base vésicules extracellulaires

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Français - Anglais

Date Limite Candidature : vendredi 30 octobre 2020

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General information

Reference : UMR7057-CARPHI-009
Workplace : PARIS,PARIS 06
Date of publication : Friday, October 09, 2020
Type of Contract : FTC Technical / Administrative
Contract Period : 12 months
Expected date of employment : 1 November 2020
Proportion of work : Part time
Remuneration : CNRS gross salary between 2141 and 2272 euros depending on experience
Desired level of education : 3-year university degree
Experience required : 1 to 4 years


The engineer (M/F) will be in charge of setting up an animal model of digestive inflammatory disease in rats.

Extracellular vesicles (EVs), in particular mesenchymal stem cells (MSCs), play a direct role in restoring tissue function and homeostasis. These EVs are increasingly considered as competent effectors as an alternative to cells for regenerative medicine in a paradigm shift from cell therapy to subcellular therapy (EV). The implementation of the EVs production protocol in GMP compliant bioreactors is a major challenge in the implementation of EV MSC production. We intend to implement a culture of MSCs in GMP bioreactors in order to produce EVs. In addition, we will develop a formulation based on the obtained vesicles combined with a hydrogel and we will test their immunomodulatory effect in vitro and in vivo in a model of colonic inflammatory disease with digestive fistula.

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The agent will also be involved in the evaluation of an extracellular vesicle-based biotherapy. The production of extracellular vesicles will be done using a method patented by our team. The agent will notably evaluate the immuno-modulation activity of these vesicles.
- Animal experimentation
- Induction of a colonic inflammatory disease model in small animals
- Administration of treatment to sick animals
- Evaluation of the therapeutic effect

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Strictly required skills: Pathophysiology of Inflammatory Bowel Chronic Diseases.
The desired agent will have a medical background with skills in gastroenterology.

Work Context

The work will take place at the MSC Med laboratory on the site of the "Saints-Pères".

The Matter and Complex Systems (MSC) laboratory (http://www.msc.univ-paris-diderot.fr/) is a joint unit of the University of Paris (Faculty of Sciences) and the CNRS, bringing together 160 researchers, teacher-researchers and technical staff, students, postdoctoral fellows and apprentices) is developing open, interdisciplinary physics in contact with chemistry, life sciences, medicine and artificial intelligence. Several large-scale projects around nano-medicine, morphogenesis, control of living organisms, cell therapies, mechanobiology and extracellular vesicles are thus developed at the MSC laboratory, in very strong interaction with numerous partners biologists, chemists and physicians, and with a strong potential for valorization.

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Constraints and risks

Usual schedule, travel to our collaborator's site at the Paris Cardiovascular Research Center (PARCC), Paris.

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