En poursuivant votre navigation sur ce site, vous acceptez le dépôt de cookies dans votre navigateur. (En savoir plus)
Portail > Offres > Offre UMR7057-CARPHI-009 - Ingénieur d'étude (H/F) sur la mise en place d'un modèle d'animal de maladie inflammatoire digestive et évaluation d'une biothérapie à base vésicules extracellulaires

Study engineer (M/F) on the implementation of an animal model of digestive inflammatory disease and evaluation of a biotherapy based on extracellular vesicles.d'un modèle d'animal de maladie inflammatoire digestive et évaluation d'une biothérapie à base vésicules extracellulaires

This offer is available in the following languages:
Français - Anglais

Date Limite Candidature : vendredi 30 octobre 2020

Assurez-vous que votre profil candidat soit correctement renseigné avant de postuler. Les informations de votre profil complètent celles associées à chaque candidature. Afin d’augmenter votre visibilité sur notre Portail Emploi et ainsi permettre aux recruteurs de consulter votre profil candidat, vous avez la possibilité de déposer votre CV dans notre CVThèque en un clic !

Faites connaître cette offre !

General information

Reference : UMR7057-CARPHI-009
Workplace : PARIS,PARIS 06
Date of publication : Friday, October 09, 2020
Type of Contract : FTC Technical / Administrative
Contract Period : 12 months
Expected date of employment : 1 November 2020
Proportion of work : Part time
Remuneration : CNRS gross salary between 2141 and 2272 euros depending on experience
Desired level of education : 3-year university degree
Experience required : 1 to 4 years

Missions

The engineer (M/F) will be in charge of setting up an animal model of digestive inflammatory disease in rats.

Extracellular vesicles (EVs), in particular mesenchymal stem cells (MSCs), play a direct role in restoring tissue function and homeostasis. These EVs are increasingly considered as competent effectors as an alternative to cells for regenerative medicine in a paradigm shift from cell therapy to subcellular therapy (EV). The implementation of the EVs production protocol in GMP compliant bioreactors is a major challenge in the implementation of EV MSC production. We intend to implement a culture of MSCs in GMP bioreactors in order to produce EVs. In addition, we will develop a formulation based on the obtained vesicles combined with a hydrogel and we will test their immunomodulatory effect in vitro and in vivo in a model of colonic inflammatory disease with digestive fistula.

Translated with www.DeepL.com/Translator (free version)

Activities

The agent will also be involved in the evaluation of an extracellular vesicle-based biotherapy. The production of extracellular vesicles will be done using a method patented by our team. The agent will notably evaluate the immuno-modulation activity of these vesicles.
- Animal experimentation
- Induction of a colonic inflammatory disease model in small animals
- Administration of treatment to sick animals
- Evaluation of the therapeutic effect

Translated with www.DeepL.com/Translator (free version)e

Skills

Strictly required skills: Pathophysiology of Inflammatory Bowel Chronic Diseases.
The desired agent will have a medical background with skills in gastroenterology.

Work Context

The work will take place at the MSC Med laboratory on the site of the "Saints-Pères".

The Matter and Complex Systems (MSC) laboratory (http://www.msc.univ-paris-diderot.fr/) is a joint unit of the University of Paris (Faculty of Sciences) and the CNRS, bringing together 160 researchers, teacher-researchers and technical staff, students, postdoctoral fellows and apprentices) is developing open, interdisciplinary physics in contact with chemistry, life sciences, medicine and artificial intelligence. Several large-scale projects around nano-medicine, morphogenesis, control of living organisms, cell therapies, mechanobiology and extracellular vesicles are thus developed at the MSC laboratory, in very strong interaction with numerous partners biologists, chemists and physicians, and with a strong potential for valorization.

Translated with www.DeepL.com/Translator (free version)

Constraints and risks

Usual schedule, travel to our collaborator's site at the Paris Cardiovascular Research Center (PARCC), Paris.

We talk about it on Twitter!