Reference : UMR7053-MATBOU-003
Workplace : VANDOEUVRE LES NANCY
Date of publication : Thursday, September 22, 2022
Type of Contract : FTC Scientist
Contract Period : 24 months
Expected date of employment : 7 November 2022
Proportion of work : Full time
Remuneration : 2,8 k € to 3,7 k €
Desired level of education : PhD
Experience required : 1 to 4 years
Keywords: Coordination chemistry; Medicinal chemistry; Optical imaging; Molecular switch.
Description: Numerous metal complexes display high therapeutic potential and their biological activity is tightly correlated to their reactivity in living systems.[1-4] Hence, the administered complexes are often pro-drugs that metabolize to active species. However, this metabolization can also be a significant source of toxicity and failure in clinical trials. Therefore, drug candidates that can be tracked by imaging and are capable to switch their signal after their bio-transformations would be a powerful tool to understand both their in cellulo fate and mode of action, for enabling their rational pharmacomodulation.[5,6]
The aim of this project is to develop innovative molecular switches to simultaneously track the localization of a series of metal-based drug candidates, and image their bio-transformations. This will allow to establish a relationship between metal's coordination sphere, metal-ligand interaction, and the complexes' reactivity toward biomolecules to understand the intricate relationship between their in cellulo reactivity and bioactivity.
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 M. Bouché, C. Hognon, S. Grandemange, A. Monari, P. C. Gros, Dalton Trans. 2020, 49 (33), 11451
 M. Bouché, P.-A. Bonnefont, T. Achard, S. Bellemin-Laponnaz, Dalton Trans. 2018, 47, 11491
 E. J. New, R. Duan, J. Z. Zhang, T. W. Hambley, Dalton Trans. 2009, 3092, 13
 L. Dondaine, D. Escudero, M. Ali, P. Richard, F. Denat, A. Bettaieb, P. LeGendre, C. Paul, D. Jacquemin, C. Goze, E. Bodio, Eur. J. Inorg. Chem. 2016, 545
The hired postdoc will work on the conception, organic synthesis of a range of functionalized ligands, their coordination to various abundant metals, and their subsequent physico-chemical, photophysical characterizations and properties in optical imaging. Cutting edge machines are available in house to carry in depth evaluation of the lead complexes. Hands-on biological testing on non pathologic cell models is a possibility. This project will involve collaborations between a group of coordination chemistry, a group of molecular biologists and a group of computational chemists.
We are looking for a skilled and highly motivated candidate with a PhD in coordination chemistry and organic chemistry. Additional experience in photophysical characterizations and optical imaging will be highly valued. Autonomy and strong reliability are required. Ability to work in cooperative environments at the chemistry-biology interface is needed for collaboration with biologists and theoretical chemists. Good English skills and scientific writing are required. Short exchanges with collaborators abroad are possible.
The work will be carried in the Laboratoire lorrain de chimie moléculaire (L2CM, UMR 7053) à l'Université de Lorraine, Nancy, France
Constraints and risks
The constraints are related to common chemical practices and chemicals' handling, and will be performed in a fully equipped and functional laboratory ensuring safety.
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