Reference : UMR6553-SYLGLE-007
Workplace : RENNES
Date of publication : Friday, November 18, 2022
Type of Contract : FTC Scientist
Contract Period : 18 months
Expected date of employment : 1 February 2023
Proportion of work : Full time
Remuneration : 2800 to 3960€ gross monthly salary, depending on experience
Desired level of education : PhD
Experience required : 1 to 4 years
The objective is to test a new theory on the evolution of the regulation of gene expression. The post-doc will set up a genomic pipeline to test the predictions of this theory, apply it to datasets already available in public databases and test the effect of certain parameters of the theory such as recombination or reproductive systems.
- Development of an analysis pipeline allowing to make the link between annotation of deleterious mutations and specific allele expression
- Application to publicly available data
- Make the tools developed available for the other partners of the project
- Dissemination of results in the form of articles and presentation at conferences
- PhD in evolutionary biology/genomics
- Knowledge of bioinformatics techniques for processing genomic data
- Programming experience for genomic data analysis (R, Python)
- Experience in using computer clusters
- Experience in the use of genomic databases and the processing of massive and heterogeneous datasets
- Ability to work in a team
- English level B2 to C1, be able to write and present scientific articles
The researcher will work within the framework of the ANR CisTransEvol project, the objective of which is to study the evolution of the regulation of gene expression in eukaryotes using evolutionary genomics approaches. More specifically, the objective is to test a theory recently proposed by the project leader* on the evolution of cis-regulators of gene expression ("run-away evolution"). A key element of this theory that will be tested is the existence of an association between allelic expression bias (determined by cis regulators) and deleterious mutations in the coding regions of genes.
[* Fyon, F., A. Cailleau, and T. Lenormand. 2015. Enhancer Runaway and the Evolution of Diploid Gene Expression. PLOS Genetics 11:e1005665.]
The recruited person will work within the scientific theme "Evolution of genomes, life history traits and adaptation" within the UMR 6553 ECOBIO under the responsibility of Sylvain Glémin (DR CNRS), partner of the ANR CisTransEvol project. He/she will work partly with the tools and the support of the genouest platform. He/she will be required to travel to Montpellier and Roscoff for meetings with project partners and to France or abroad for scientific conferences.
Constraints and risks
Work-related risks are those associated with prolonged screen work.
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