POSTDOCTORAL RESEARCHER (M/F) Biomaterials Design, Injectable Nanozeolite-containing Hydrogels and Surface Engineering for Precision Glioblastoma Therapy

Job Description

Missions

The ONCOPIT project aims to develop next-generation biomaterials based on surface-modified nanozeolites for local and systemic treatment of glioblastoma. The project integrates materials science, biomaterials engineering, controlled therapeutic delivery, cancer immunotherapy, and regenerative medicine to develop injectable zeolite-based hydrogels capable of eradicating residual tumour cells while promoting neural tissue repair and neuroregeneration.
The successful candidate will join a multidisciplinary research team working at the interface of materials chemistry, biomaterials engineering, biology, and translational medicine. The project offers a unique opportunity to contribute to the development of innovative therapeutic biomaterials through close collaboration with national and international partners.
The successful candidate will work within a newly established interdisciplinary research group at the Laboratory of Catalysis and Spectrochemistry (LCS, CNRS) in Caen, France. The project provides access to state-of-the-art facilities for materials synthesis, physicochemical characterization and biomaterials development, and offers opportunities to collaborate with leading national and international researchers in biomaterials, cancer immunotherapy and regenerative medicine.

Activity

The successful candidate will:
• Design and synthesize multifunctional biomaterials based on hierarchically porous zeolites.
• Develop surface functionalization and bioconjugation strategies for therapeutic molecules.
• Investigate hydrogel gelation mechanisms complying with its injection and tumor microenvironment condition, and study of injectability and degradation mechanism and kinetics
• Study pH- and light-responsive therapeutic release from zeolite-based hydrogels.
• Perform comprehensive physicochemical, structural, morphological and rheological characterization of the developed biomaterials.
• Collaborate closely with the biology postdoctoral researcher and the PhD student to optimize biomaterial performance for biological evaluation.
• Analyse experimental data, prepare scientific manuscripts, and present research findings at national and international conferences.

Your Profil

Skills

Applicants should hold a PhD in one of the following disciplines:
• Biomaterials
• Materials Science
• Materials Chemistry
• Biomedical Engineering
• Chemical Engineering
• Pharmaceutical Sciences
• Related disciplines
Candidates with demonstrated expertise in the design and development of injectable or in situ-forming hydrogels are particularly encouraged to apply.

Applicants should demonstrate strong hands-on experience in several of the following areas:
• Biomaterials design and synthesis
• Injectable and/or in situ-forming hydrogel systems
• Hydrogel crosslinking mechanisms and gelation kinetics
• Injectable biomaterials for local therapeutic delivery
• Hierarchically porous zeolites or other porous inorganic biomaterials
• Surface functionalization and bioconjugation
• Controlled therapeutic loading and release
• Biomaterial characterization and structure–property relationships
• Rheological and mechanical characterization of hydrogels
• Physicochemical characterization techniques (FTIR, Raman, XPS, TGA, DSC)
• Electron microscopy (SEM, TEM)
• Dynamic Light Scattering (DLS) and Zeta Potential measurements

Your Work Environment

The successful candidate will work within a newly established interdisciplinary research group at the Laboratory of Catalysis and Spectrochemistry (LCS, CNRS) in Caen, France. The project provides access to state-of-the-art facilities for materials synthesis, physicochemical characterization and biomaterials development, and offers opportunities to collaborate with leading national and international researchers in biomaterials, cancer immunotherapy and regenerative medicine.
site internet : https://www.lcs.ensicaen.fr/

Compensation and benefits

Compensation

Between 3071,50 € et 4258,37€ gross per month based on experience

Annual leave and RTT

44 jours

Remote Working practice and compensation

Pratique et indemnisation du TT

Transport

Prise en charge à 75% du coût et forfait mobilité durable jusqu’à 300€

About the offer

About the CNRS

The CNRS is a major player in fundamental research on a global scale. The CNRS is the only French organization active in all scientific fields. Its unique position as a multi-specialist allows it to bring together different disciplines to address the most important challenges of the contemporary world, in connection with the actors of change.

CNRS

The research professions