POSTDOCTORAL RESEARCHER (M/F) Biomaterials for Glioblastoma Immunotherapy, Tumor Microenvironment and Neuroregeneration
New
- Researcher in FTC
- 18 months
- Doctorate
This offer is available in English version
This offer is open to people with a document recognizing their status as a disabled worker.
Offer at a glance
The Unit
Laboratoire de catalyse et spectrochimie
Contract Type
Researcher in FTC
Working hHours
Full Time
Workplace
14050 CAEN
Contract Duration
18 months
Date of Hire
01/12/2026
Remuneration
Between 4258,37 € and 4439,55€ gross per month based on experience
Apply Application Deadline : 21 September 2026 23:59
Job Description
Missions
The ONCOPIT project aims to develop innovative injectable zeolite-based biomaterials for the local treatment of glioblastoma by combining biomaterials engineering, cancer immunotherapy and regenerative medicine. The project seeks to understand how engineered biomaterials interact with the tumour microenvironment to induce anti-tumour immune responses while simultaneously promoting neural tissue repair and neuroregeneration following tumour treatment.
The successful candidate will work in a multidisciplinary team at the interface of biomaterials, cancer biology, immunology and regenerative medicine.
Activity
The successful candidate will:
• Evaluate the biological performance of injectable zeolite-based biomaterials using relevant glioblastoma models.
• Investigate protein corona formation, its composition and evolution under physiological conditions, and its influence on the biological identity of engineered biomaterials.
• Study biomaterial–cell interactions, including cellular uptake, intracellular trafficking and intracellular localization.
• Evaluate the influence of protein corona formation on cellular uptake, therapeutic efficacy and tumour microenvironment modulation.
• Investigate the mechanisms of immunogenic cell death (ICD) following biomaterial-mediated phototherapy.
• Evaluate cytocompatibility, phototoxicity and therapeutic efficacy using two-dimensional and three-dimensional glioblastoma models.
• Develop and perform in vivo studies to assess biomaterial injectability, biodistribution, biological performance and therapeutic efficacy.
• Contribute to the biological evaluation of tissue repair and neuroregeneration in collaboration with experts in neuroregenerative medicine.
• Perform flow cytometry, confocal microscopy, immunofluorescence, histology and immunohistochemistry analyses.
• Collaborate closely with the materials science postdoctoral researcher and the PhD student to optimize biomaterial design based on biological feedback.
• Prepare scientific publications and present research findings at national and international conferences.
Your Profil
Skills
Applicants should have strong hands-on experience in several of the following areas:
• Biological evaluation of biomaterials
• Protein corona analysis and nano–bio interactions
• Biomaterial–cell interactions
• Mammalian cell culture
• Glioblastoma biology
• Immunogenic cell death (ICD)
• Cellular uptake and intracellular trafficking
• Cytotoxicity and phototoxicity assays
• Flow cytometry
• Confocal and fluorescence microscopy
• Immunofluorescence and immunohistochemistry
• Histopathological analysis
• Small-animal experimentation
• In vitro and/or in vivo evaluation of biomaterials
Experience with glioblastoma models, protein corona characterization, phototherapy, or biomaterial-based cancer therapy will be considered a strong advantage. Previous experience in neuroregeneration is desirable but not mandatory, as this aspect of the project will be carried out in close collaboration with experts in regenerative medicine and neuroscience.
Your Work Environment
This project is being carried out at the Catalysis & Spectrochemistry Laboratory in Caen, Normandy. The successful candidate will be supervised by Professor Hajar Maleki.
The successful candidate will be based at the LCS and will work closely with the Imaging and Therapeutic Strategies for Cancers and Brain Tissues (ISTCT) – Cyceron in Caen.
Compensation and benefits
Compensation
Between 4258,37 € and 4439,55€ gross per month based on experience
Annual leave and RTT
44 jours
Remote Working practice and compensation
Pratique et indemnisation du TT
Transport
Prise en charge à 75% du coût et forfait mobilité durable jusqu’à 300€
About the offer
| Offer reference | UMR6506-MARLEC-040 |
|---|---|
| CN Section(s) / Research Area | Chemistry of and for life: design and properties of molecules of biological interest |
| Relevant experience | 5 to 10 years |
About the CNRS
The CNRS is a major player in fundamental research on a global scale. The CNRS is the only French organization active in all scientific fields. Its unique position as a multi-specialist allows it to bring together different disciplines to address the most important challenges of the contemporary world, in connection with the actors of change.
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