Research Engineer (M/F) in Bioorganic Chemistry / Chemical Biology
New
- Researcher in FTC
- 10 mounth
- Doctorate
This offer is available in English version
This offer is open to people with a document recognizing their status as a disabled worker.
Offer at a glance
The Unit
Chimie Et Interdisciplinarité : Synthèse, Analyse, Modélisation
Contract Type
Researcher in FTC
Working hHours
Full Time
Workplace
44322 NANTES
Contract Duration
10 mounth
Date of Hire
27/04/2026
Remuneration
Gross salary ranging from €3,000 to €4,500 per month depending on experience
Apply Application Deadline : 18 March 2026 23:59
Job Description
Missions
We have recently developed an electrochemical bioconjugation strategy enabling the site-selective anchoring of a chemical handle onto tyrosine residues of proteins through the application of a simple electrical potential in solution. This electro-bioconjugation reaction occurs within minutes, providing a rapid and biocompatible method for functionalizing viral vectors, bacteria, and even whole cells without compromising their viability (Nat. Commun., 2023, 14, 5122; Chem. Sci., 2021, 12, 15374–15381; J. Am. Chem. Soc., 2018, 140, 17120–17126).
In this project, the successful candidate will develop the chemical synthesis of complex sugar conjugates and functionalize them with a bioorthogonal group activatable via electrochemical stimulation. These compounds will then be grafted by electro-click chemistry onto Natural Killer (NK) lymphocytes in order to more effectively target SIGLEC-type receptors overexpressed in certain cancers (e.g., acute myeloid leukemia).
Activity
-Functionalization of oligosaccharides
-Electrochemical bioconjugation reactions on cells
-Characterization of synthesized products and conjugation reactions
-Preparation of scientific reports
Your Profil
Skills
-Expertise in glycochemistry and/or bioorganic chemistry and chemical biology
-Ability to work as part of a team
-Ability to present scientific work at group meetings
Your Work Environment
The work will be carried out within the framework of the INCA NK-ELITE project, led by Christelle Retière (CRCI2NA).
This project will be conducted in collaboration with several research groups in Nantes, including the TaRGeT laboratory, under the supervision of Mathieu Mével.
The recruited postdoctoral researcher will carry out their research under the supervision of Sébastien Gouin within the CORAIL team at the CEISAM laboratory (Nantes Université).
Electrochemical grafting experiments on cells will be performed at the TaRGeT and CRCI2NA laboratories, both located in Nantes.
Compensation and benefits
Compensation
Gross salary ranging from €3,000 to €4,500 per month depending on experience
Annual leave and RTT
44 jours
Remote Working practice and compensation
Pratique et indemnisation du TT
Transport
Prise en charge à 75% du coût et forfait mobilité durable jusqu’à 300€
About the offer
| Offer reference | UMR6230-SEBGOU-013 |
|---|---|
| CN Section(s) / Research Area | Chemistry of and for life: design and properties of molecules of biological interest |
About the CNRS
The CNRS is a major player in fundamental research on a global scale. The CNRS is the only French organization active in all scientific fields. Its unique position as a multi-specialist allows it to bring together different disciplines to address the most important challenges of the contemporary world, in connection with the actors of change.
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