Postdoctoral positions (M/F) in Oligosaccharide synthesis/Chemical biology
New
- Researcher in FTC
- 12 mounth
- Doctorate
This offer is available in English version
This offer is open to people with a document recognizing their status as a disabled worker.
Offer at a glance
The Unit
Chimie Et Interdisciplinarité : Synthèse, Analyse, Modélisation
Contract Type
Researcher in FTC
Working hHours
Full Time
Workplace
44322 NANTES
Contract Duration
12 mounth
Date of Hire
20/04/2026
Remuneration
€3,000 to €4,500 gross per month depending on experience.
Apply Application Deadline : 18 March 2026 23:59
Job Description
Missions
Cell surfaces display a large number of oligosaccharides which, depending on their structure, play a key role in immunity, adhesion, and cell–cell communication processes.
The ability to modify cell surfaces with well-defined natural oligosaccharides therefore offers highly promising opportunities to target or confer new properties to viral and cellular vectors in the field of gene and cell therapy. However, the vast majority of complex natural sugars are not commercially available.
This research project aims to synthesize natural oligosaccharides (heparin-derived structures and oligomannosides) capable of interacting with specific cellular receptors.
Once synthesized, these ligands will be grafted onto viral vectors (AAVs) used in gene therapy in order to improve their tropism and infectivity.
Bioconjugation will be carried out using a click-electrochemistry strategy developed within the group, enabling the rapid decoration of bacteria and living cells within minutes without affecting their viability [Nat. Commun., 2023, 14, 5122; Chem. Sci., 2021, 12, 15374–15381; J. Am. Chem. Soc., 2018, 140, 17120–17126].
The recruited postdoctoral researcher will primarily be responsible for the synthesis of specific natural oligosaccharides and will also perform their functionalization with bioorthogonal groups activatable through electrochemical methods.
Activity
-Multi-step synthesis of natural oligosaccharides
-Electrochemical bioconjugation reactions
-Characterization of synthetic products and conjugates
-Preparation of scientific reports
-Presentation of research at conferences and scientific meetings
Your Profil
Skills
-Expertise in glycochemistry and/or bioorganic chemistry and chemical biology
-Ability to work effectively as part of a team
-Ability to present scientific results at group meetings
Your Work Environment
The recruited postdoctoral researcher will conduct their work under the supervision of Sébastien Gouin, within the CORAIL team at the CEISAM laboratory (Nantes Université). The project will be carried out in collaboration with other Nantes-based research groups, in particular the TaRGeT laboratory, under the supervision of Mathieu Mével.
Compensation and benefits
Compensation
€3,000 to €4,500 gross per month depending on experience.
Annual leave and RTT
44 jours
Remote Working practice and compensation
Pratique et indemnisation du TT
Transport
Prise en charge à 75% du coût et forfait mobilité durable jusqu’à 300€
About the offer
| Offer reference | UMR6230-SEBGOU-012 |
|---|---|
| CN Section(s) / Research Area | Chemistry of and for life: design and properties of molecules of biological interest |
About the CNRS
The CNRS is a major player in fundamental research on a global scale. The CNRS is the only French organization active in all scientific fields. Its unique position as a multi-specialist allows it to bring together different disciplines to address the most important challenges of the contemporary world, in connection with the actors of change.
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