Post-doctoral position (M/F) - Organic synthesis

Job Description

Missions

Diazo compounds display extremely diverse reactivities with a high atom efficiency, offering them many applications in organic synthesis. Despite ther versatility, diazo compounds are partly renown because of their instability. To this day, most of the methods allowing their synthesis are targeted towards the most stable diazo compounds, namely the ones stabilized by an electron-withdrawing group on the adjacent carbon atom.
This project aims to develop new synthetic routes toward semi‒ and non‒stabilized diazo compounds, using simple substrates, to finally broaden their uses in organic synthesis. The project will be developped within the team "Synthèse de biomolécules fluorées" at the CARMeN Institute (UMR 6064), undr the supervision of Dr Margaux Riomet.

Activity

This project will consist in synthetic methodology for the preparation of diazo compounds. Those species will be formed and then immediately trapped (in a batch reactor for semi-stabilized diazos, in continuous flow for non-stabilized diazos). The recruited candidate will synthesize the envisaged substrates and then screen different reaction conditions to obtain diazo compounds. The obtained molecules will be identified and caracterized using standard analysis techniques (NMR, high resolution mass ...). Le mechanism at play in the transformation will also be studied.

Your Profil

Skills

Applicants must hold a PhD in molecular chemistry and have less than 2 years of post-doctoral experience. The candidate must have stong theoretical knowledge and practical skills. The recruited candidate must be rigorous, capable of proposing synthesis strategies, highly motivated, and hardworking. Experience in continuous flow chemistry is not required.

Your Work Environment

This project is funded by the Normandy Region within the "Projet émergent" program under the acronym NorMaDiazo. It will be carried out at the CARMeN Institute (Rouen site), within the team "Synthèse de biomolécule fluorées. The team focuses on the use of emerging technologies, such as photocatalysis, electrosynthesis and flow chemistry , for the establishment of novel synthetic methods.

Constraints and risks

The recruited candidate will work with standard reagents and solvents in organic synthesis and must therefore follow standard handling procedures: wearing personal protective equipment (safety glasses, lab coat), working under a fume hood when necessary, etc. Working alone in the laboratory is not permitted. The recruited candidate must organize their schedule and leave in such a way that at least one other team member is always present in the workplace.

Compensation and benefits

Compensation

From €3,072 to €3,500 gross per month, depending on experience and the current CNRS salary scale.l'expérience et la grille de rémunération en vigueur du CNRS

Annual leave and RTT

44 jours

Remote Working practice and compensation

Pratique et indemnisation du TT

Transport

Prise en charge à 75% du coût et forfait mobilité durable jusqu’à 300€

About the offer

About the CNRS

The CNRS is a major player in fundamental research on a global scale. The CNRS is the only French organization active in all scientific fields. Its unique position as a multi-specialist allows it to bring together different disciplines to address the most important challenges of the contemporary world, in connection with the actors of change.

CNRS

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