Missions

The candidate will conduct an in-depth study on the use of nanoparticles as radiosensitizing agents, with the aim of improving the efficacy of radiotherapy for glioblastoma, an aggressive form of brain tumor.

Activities

In vitro radiobiology studies.
Preparation of cell cultures for injection into rodents.
Injection of nanoparticles prior to radiotherapy sessions.
The candidate will assess tumor growth using MRI imaging.
At the end of the protocol, the candidate will study the tissue effects of the injections through immunohistochemistry.

Skills

The candidate will be able to independently conduct cell culture studies for radiobiology experiments. They will also be capable of performing autonomous tumor cell implantation in an orthotopic model in the brain, as well as carrying out radiotherapy, MRI imaging, and immunohistochemistry experiments. Training in animal experimentation is desirable. Additionally, knowledge in neuro-oncology and cancer treatments would be considered an advantage. The candidate must be proficient in English.

Work Context

The ISTCT "Imaging and Therapeutic Strategies for Cancer and Brain Tissues" unit (UMR6030) is a joint research unit of the CNRS and the University of Caen-Normandie, hosted at the GIP CYCERON in Caen. ISTCT brings together around fifty individuals, including researchers, university professors, clinicians, technicians/engineers, and students from diverse backgrounds, fostering the development of fundamental, pre-clinical, and clinical research. The research activities at ISTCT aim to better understand the pathophysiology of hypoxic tumors (brain-lung) and identify new therapeutic strategies targeting the tumor and its microenvironment, while also protecting the surrounding healthy tissue from anti-cancer treatments such as radiotherapy. This research is part of a collaboration with the LCS laboratory in Caen.