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Reference : UMR5819-YOAROU-002
Workplace : GRENOBLE
Date of publication : Thursday, January 30, 2020
Type of Contract : FTC Scientist
Contract Period : 16 months
Expected date of employment : 1 April 2020
Proportion of work : Full time
Remuneration : 2,600-3,000 euros before taxes according to experience
Desired level of education : 5-year university degree
Experience required : Indifferent
The candidate will be in charge of the development, characterization and operation of a biosensor dedicated to the detection of pathogenic bacteria present in a blood test. This work is part of a larger project, funded for three years by the French National Research Agency (Bacus Project) and launched in December, 2018. This project gathers three laboratories located in Grenoble: the SyMMES lab (laboratory for Molecular Systems and nanoMaterials for Energy and Health), the DCM (department of Molecular Chemistry), and the Grenoble General Hospital. The candidate will mainly work at the SyMMES laboratory but will also lead experiments in the two other partner facilities. The candidate will thus be aware of the challenge for working in such environment and will be in charge of sharing results and data between the three labs. The candidate will be expected to show initiative and imagination and to be highly motivated.
This job opportunity is at the crossroad of different scientific domains. Indeed, the project will deal with:
- surface functionalization with peptides (skills and expertise managed by our consortium);
- standard techniques of microbiology (bacteria seeding, culture, colony counting, cryo-preservation, etc.), in Biosafety Level 2 labs (skills and expertise managed by our consortium);
- handling and processing of Human blood (skills and expertise managed by our consortium);
- biosensor data analysis using bio-statistical tools like Principal Component Analysis;
- punctually, the candidate may be in charge of the solid phase synthesis of peptides (skills and expertise managed by our consortium).
Candidates must have a strong expertise in applied microbiology (for heath issues) with knowledge on bio-statistics; and/or some experience in optical instruments or biosensors. Experience in Principal Component Analysis will be greatly appreciated. Regarding the technical skills, candidates must have some experience in standard optical microscopic methods (fluorescence) and/or in Surface Plasmon Resonance.
The selected candidate will have remarkable skill for getting quickly familiar with scientific domains specific to each partner. The candidate will be quite autonomous although regular reporting within the consortium is mandatory. This researcher will deal with surface chemistry, biomedical microbiology, biological data statistical analysis, along with instrumental and biosensor design. The success will partly rely on the candidate rigor, autonomy and dedication to the project. The selected candidate will have strong skills in summarizing, presenting and publishing his results. The researcher will by largely involved in oral presentations (international conferences for instance) and reports to be produced for the ANR follow up.
Any candidate will give (at least) two independent references of PIs supervising their previous projects (mandatory).
This project is part of a long lasting collaboration of these three partners. This collaboration started several years ago and got funded by alternative. The researcher to be hired should start during the first 2020 semester (April), for a 16 months duration. The SyMMES lab has a long experience (> 18 years) in leading multidisciplinary projects, which guarantees the ideal environment for such a project.
Constraints and risks
This project requires the handling and processing of Human blood. All samples will be tested for their innocuousness before getting using. The SyMMES lab has two Biosafety Level 2 facilities; one being dedicated to experiments with pathogenic bacteria while the other is dedicated to Human blood samples. The candidate will attend training sessions for each experimental risk he might be exposed to (for instance: Chemical safety training, Biosafety training, Safety in an experimental laboratory).
2,000-2,300 euros/month after taxes according to the candidate experience
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