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Reference : UMR5798-THOSAL-005
Workplace : TALENCE
Date of publication : Tuesday, October 5, 2021
Type of Contract : FTC Scientist
Contract Period : 12 months
Expected date of employment : 3 January 2022
Proportion of work : Full time
Remuneration : 2663€ - 3069€ depending on past experience
Desired level of education : PhD
Experience required : 1 to 4 years
The motility of microscopic biological entities in order to reach specific targets is a central question of biophysics, as evidenced by: cancer metastases, durotaxis of stem cells, recognition of antibodies or DNA replication, among many other examples. In an attempt at idealization, this problem could be reduced to simple mechanics through a combination of essential ingredients: viscous flow, elastic limits, confined environment, loads and fluctuations. Therefore, combining ingredients from the continuum such as hydrodynamics and elasticity, as well as small-scale molecular fluctuations, appears to be a crucial task. From the above arguments, the study of Brownian motion in soft and lubricated environments emerges as one of the canonical problems of biophysics and nanophysics. Despite the obvious nature of this proposition, it is fascinating that experimental studies are non-existent. The present project therefore naturally aims to fill this gap. Our strategy is to develop equilibrium holographic microscopy experiments, with free micrometric colloidal probes evolving near various soft substrates, in order to reveal the fundamental coupling between random mobility and the softness of neighboring borders. The team has developed complementary experimental approaches as well as theoretical methods which will be very beneficial for the project.
- Preparation of samples
- Interferometric measurements of colloids in lubricated / confined environments
- Data analysis
- Analytical and numerical modeling
- Writing of articles and oral communications
- Strong expertise in microscopy, soft matter and statistical physics
- Expertise in numerical methods; machine learning highly encouraged
- Excellent written and oral communication skills (English), including standard tools (LaTeX, etc.)
LOMA is a physics laboratory located at the University of Bordeaux. Its activities encompass hard and soft condensed matter, including biological matter, as well as optics. It typically includes 50 permanent staff and a similar number of non-permanent staff and students. The recruited researcher will belong to both the “photonics and materials” team and the “condensed matter theory” team.
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