Reference : UMR5629-ELIGAR-001
Workplace : PESSAC
Date of publication : Wednesday, November 16, 2022
Type of Contract : FTC Scientist
Contract Period : 18 months
Expected date of employment : 30 January 2023
Proportion of work : Full time
Remuneration : Between 2 805€ and 3 963€ gross monthly depending on experience
Desired level of education : PhD
Experience required : Indifferent
The person recruited will work on the chemoselective modifications of recombinant elastin polypeptides (ELPs) as part of the European project “Force Repair”. He/She will provide the project partners with batches of characterized ELPs bioconjugates. He/She will provide analytical data sheets and write reports in English. He/She will integrate the LCPO team 3 and contribute to the common tasks. She may be required to supervise interns (2-6 months). He/She will make presentations in English of the results of his/her research project.
- Organic synthesis: chemoselective post-modification reactions of recombinant polypeptides
- Chemical (NMR, mass spectrometry, chromatography) and physico-chemical (turbidimetry, rheology) analyses
- Drafting of analytical data sheets
- Writing of reports
- Participation in the team's responsibilities and common tasks
- Organic synthesis and/or bioconjugation chemistry
- Chemical analysis techniques (NMR, MS, HPLC, SEC)
- Fluent English (oral and written)
The Laboratory of Chemistry of Organic Polymers (LCPO) is a joint research unit affiliated to the CNRS, the University of Bordeaux and the Institut Polytechnique de Bordeaux (http://www.lcpo.fr). The LCPO is organized into 4 research teams with a total strength of nearly 150 people, including about 50 permanent staff.
With over 30 years of expertise in polymer chemistry, researches at LCPO aim at:
- developing innovative methodologies for precision synthesis of polymers, using in particular biomimetic and/or green chemistry pathways
- designing functional polymer materials by macromolecular engineering and self-assembly, in the fields of renewable materials, health and energy
- establishing strong links with the socio-economy world.
The work of the recruited agent will be carried out within the LCPO team 3 and in collaboration with various academic and industrial partners in the framework of the European Force Repair project.
Team 3 entitled "Self-assembly of Polymers and Life Sciences" is headed by Sébastien Lecommandoux. The team explores the design biomimetic and biofuntional nano and microparticles, especially polymersomes, with the following main focus:
- synthesis and self-assembly of block copolymers based on polypeptides, polysaccharides and proteins
- formulation of functional nanoparticles, including polymersomes, for the targeted delivery and controlled release of active ingredients (therapy and theranostic)
- design of artificial cells (protocells) as membrane models and biological factory.
Constraints and risks
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