Intitulé de l'offre : Engineer on design and production of devices for multisite electrical stimulation of brain slices (H/F)
Référence : UMR5588-MARCAN-006
Nombre de Postes : 1
Lieu de travail : ST MARTIN D HERES
Date de publication : vendredi 31 mars 2023
Type de contrat : CDD Technique/Administratif
Durée du contrat : 18 mois
Date d'embauche prévue : 1 juillet 2023
Quotité de travail : Temps complet
Rémunération : Monthly, between 2213,87€ and 2642,82€ before taxes according to the experience
Niveau d'études souhaité : Niveau 7 - (Bac+5 et plus)
Expérience souhaitée : 5 à 10 années
BAP : Sciences de l'Ingénieur et instrumentation scientifique
Emploi type : Ingénieur-e en conception instrumentale
This project aims at developing novel technologies to be transferred to preclinical research at academic and industrial level. It also aims at partially replacing animal research in vivo by using brain slices (ex vivo). The project consists at conceive and produce arrays of micro-stimulators with architecture adapted to the anatomy of the brain slice in order to replicate the physiological electrical activity and, this way, to test novel treatments. At a longer time scale, these technologies will be integrated in imaging systems allowing automating the tests and this follow-up will involve the construction of a start-up in collaboration with existing companies in the field. The recruited engineer will be able to participate to the start-up setting and eventually to work for it.
The engineer must
• Conceive the arrays of micro-stimulators and produce them with different manufacturing techniques, starting from the use of 3D printers up to lithography and use of clean room to achieve the precision in the order of a micron.
• Develop a program to design the geometry of the arrays as a function of the morphology of the brain slice to study.
• After production, incorporate to the arrays the current generators controlled by a computer.
• Integrate the stimulating system in a electrophysiology/imaging workstation for brain slices.
The candidate must have experience in micro-manufacturing and computer programming. Ideally, the candidate must have the following knowledge and skills:
• Use of 3D printers and/or experience in clean rooms.
• Computer programming at least in either C++ or python.
• General knowledge in electronics.
In addition, the candidate must have a very strong motivation for scientific research as well as a genuine will to continue the project after its end towards the setting of the start-up.
Contexte de travail
The engineer will work at the CNRS Laboratory of Interdisciplinary physics (https://liphy.univ-grenoble-alpes.fr/) in the Grenoble university campus where the project will take place. The project will benefit from a collaboration with other laboratories in the campus or in the CEA/MINATEC site that will put their infrastructure at disposal of this collaboration.
Contraintes et risques