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Reference : UMR5588-GIOCAP-002
Workplace : ST MARTIN D HERES,ST MARTIN D HERES
Date of publication : Monday, October 05, 2020
Type of Contract : FTC Scientist
Contract Period : 24 months
Expected date of employment : 1 January 2021
Proportion of work : Full time
Remuneration : Between 2648 and 3768€ gross monthly, depending on experience
Desired level of education : PhD
Experience required : Indifferent
Supra-cellular organization is crucial to establish and maintain the structure, function and homeostasis of biological tissues. The reaction-diffusion framework justifies the emergence of morphogenetic patterns from an initially uniform distribution of biochemical molecules controlling cell fate. However, an increasing number of recent studies indicate that cell proliferation and differentiation are also impacted by the dynamic reciprocity between cell mechanical activity and the physical properties of their microenvironment.
Several recent works reported that wave-like patterns of the velocity spontaneously appear in colonies of epithelial cells. Those supra-cellular waves appear in spreading epithelial sheets, and become stationary in confined geometries where cell migration is limited to internal rearrangements. Strikingly, supra-cellular waves are characterized by precise wavelength and period.
In this project, we will investigate whether supra-cellular waves induce a spontaneous transcriptomic divergence between the cells situated in the wave nodes and those located in the antinodes of the standing wave.
The post-doc will
- investigate the biophysical nature of supra-cellular waves and their resilience (collaboration with the theoreticians at Laboratoire Interdisciplinaire de Physique).
- test the impact of standing supra-cellular waves on local transcriptomic (collaboration with the team "Mechanotransduction and Nuclear functions" at the Institute for Advanced Biosciences)
The post-doc candidate should have a background and training in biophysics. Experience in data analysis, simulation and cell culture would be appreciated.
The Laboratoire Interdisciplinaire de Physique (LIPhy) is a joint research unit (UMR 5588) under the supervision of the CNRS and the University of Grenoble Alpes. LIPhy is located on the university campus of Saint-Martin d'Hères, east of Grenoble. The laboratory has about 150 members including 66 researchers and professors, 32 engineers, technical and administrative staff and 39 PhD students. The laboratory is structured in seven teams working in different fields mainly in the fields of optics, complex matter and living matter.
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