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Portail > Offres > Offre UMR5588-DELDEB-001 - H/F Postdoc : mesure de forces d'adhésion de bactéries sur des surfaces de rigidité contrôlée

Postdoc : measuring adhesion forces of bacteria onto substrates of controlled rigidity

This offer is available in the following languages:
Français - Anglais

Date Limite Candidature : lundi 26 octobre 2020

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General information

Reference : UMR5588-DELDEB-001
Workplace : ST MARTIN D HERES,ST MARTIN D HERES
Date of publication : Monday, October 05, 2020
Type of Contract : FTC Scientist
Contract Period : 24 months
Expected date of employment : 1 January 2021
Proportion of work : Full time
Remuneration : gross salary: from 2648 euros to 3768 euros / month depending on the experience of the candidate
Desired level of education : PhD
Experience required : Indifferent

Missions

The HiTrac project funded by the French National Research Agency (ANR) aims to develop methods for adhesion force measurements to study quantitatively bacterial adhesion in its micromechanical environment. At the crossroad between biophysics, physico-chemistry and microscopy, our goal is to develop and use innovative adhesion substrates for traction force microscopy, a technique already well established to quantify adhesion forces of eukaryotic cells.
Building on preliminary results obtained in the lab, the successful candidate will design and use new adhesion substrates with controlled mechanical properties that will permit measuring adhesion forces with improved resolution and sensitivity compared to existing techniques. In collaboration with the physics department at ENS Lyon, she/he will use the substrates for proof-of-principle demonstrations and biophysical studies of the mechanical regulation of bacterial adhesion.

Activities

- Design, synthesis and characterization of innovative substrates for TFM
- Integration in microfluidic devices for biophysics experiments, data analysis (in particular image analysis)
- Scientific watch and analysis of publication related to the project
- Preparation of regular advancement reports presented during regular meetings of the project partners
- Writing of one or several scientific papers, participation in national/international conferences in the field of biophysics/soft matter

Skills

We are looking for a rigorous experimental soft matter physicist/chemist, or biophysicist, with a keen interest in multidisciplinary work. Experience in microscopy and/or image analysis will be greatly appreciated. Experience with biological samples, programming and/or microfluidic is a plus.

Work Context

Grenoble is a pleasant city located in the French Alps. It is one of the most renowned scientific areas in France, providing a vibrant and collaborative scientific environment. The Laboratory of Interdisciplinary Physics (LIPhy) at the University Grenoble Alpes brings together researchers in soft matter physics, biophysics, physico-chemistry, biology and optics.
The successful applicant will be hosted in the research group Mechanics of Cells in Complex Media (MC2). He/she will work under the supervision of Dr. Delphine Débarre and Dr. Lionel Bureau, in close collaboration with Dr. Sigolène Lecuyer at the Ecole Normale Supérieure (Lyon, France). While close supervision will be provided a strong independence is expected.

Constraints and risks

The bacterial model system is the opportunistic pathogen P. Aeruginosa which can cause health problem to immunocompromised people or in case of pregnancy. In such cases adjustments will be discussed to mitigate the risk. In all cases appropriate health & safety training will be provided.

Additional Information

Interested candidates should apply through the CNRS dedicated webpage and include a motivation letter, CV, and contact information of two referees.

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