Missions

During embryonic development, cellular identities are progressively established with a striking accuracy and reproducibility. This is in part due to precise regulation of gene expression in space and time. Our understanding of gene expression control during development, with some exceptions, is mostly based on mRNA studies, ignoring potential regulatory inputs from translation. While precision at the transcriptional level is well documented, much less is known concerning protein synthesis, which is not necessarily linearly related to transcription. How is the translation process regulated in space and time during development? To what extent translation efficiency differs between identical mRNAs, targeted to distinct subcellular compartments?
This project aims to unravel the mechanisms underlying the lack of correlation between mRNA and proteins levels to elucidate the sources of reproducible cell fate decisions during development. The project leader will primarily use quantitative imaging in Drosophila embryos combined with genetic/optogenetic manipulations.

Activités

-lead a research project
-drosophila genetics
-quantitative imaging and image analysis
-genomics
-collection of embryos and stainings
-cloning

Compétences

Prior experience with molecular biology, genetics or microscopy are essential.
Strong interest in developmental or cell biology.
Prior knowledge in Drosophila genetic will be valuable.
Ability to work as part of an international team is required.
Good communication skills (written reports and oral presentations)
A PhD in biology, biophysics or a closely related field is required by the start of the appointment. Interdisciplinary profiles are strongly encouraged to apply.

Contexte de travail

The post-doctoral fellow will join the IGMM, which is a pluri-thematic CNRS research unit, offering an environment perfectly suited to the development of the proposed subject. IGMM, is located on the historic CNRS Montpellier "Route de Mende" campus. It is physically connected to CRBM and IRIM research institutes, forming a critical mass of 600 people who create an exceptional intellectual and technological dynamic environment. The labs at IGMM have access to high-tech facilities, in particular through BioCampus. Contract funded under the European Research Council (ERC) project.