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Portail > Offres > Offre UMR5525-ELSGEN-012 - Post-doctorant (H/F) en biomécanique des tissus du vivant

Post-doctorant (M/F) in biomechanics of living tissue

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Français - Anglais

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General information

Reference : UMR5525-ELSGEN-012
Workplace : LA TRONCHE
Date of publication : Saturday, September 12, 2020
Type of Contract : FTC Scientist
Contract Period : 12 months
Expected date of employment : 1 December 2020
Proportion of work : Full time
Remuneration : Between 2648 and 3054 € brut per month, according to experience
Desired level of education : PhD
Experience required : 1 to 4 years

Missions

The aim of this post-doctorate is to model the mechanical interaction between a dressing and a pressure sore using the Finite Element Method. It will take place at the TIMC-IMAG laboratory in Grenoble, which has a strong track record in biomechanical modelling of soft tissues, in collaboration with the URGO Company, the French leader in dressings.
Generally speaking, pressure ulcers and pressure sores were defined in 1989 by the National Pressure Ulcer Advisory Panel as skin lesions of ischaemic origin linked to a compression of the soft tissues between a hard surface and a bony protrusions. While the formation of such wounds is multifactorial, a distinction is made between (i) extrinsic or mechanical risk factors such as immobility, hyperpressure, friction, shear or maceration and (ii) intrinsic or clinical risk factors such as age, nutritional status, skin condition, sensory or motor, vascular, metabolic neurological pathologies. However, the interface pressure between the skin and the support represents the most important factor in the formation of bedsores and ulcers. This is why they are called "pressure ulcers".
In recent years, many efforts have been made to improve the quality of interface supports with the main objective of better pressure distribution on the soft tissue surface. This has resulted in a number of advances and in particular the flourishing of cushion and/or mattress manufacturers. With the same objective of distributing pressure over anatomical areas that are often prone to wounds such as the sacrum or heel, the dressing industry has proposed a "prophylactic" use of these dressings, i.e. their application to healthy skin, in order to act as a "protective cushion" that aims to mechanically absorb surface pressure.
This research project takes a new step in the treatment of pressure ulcers by attempting to quantify the "protective cushion" effect a dressing may have on an already formed wound.

Activities

While the ischaemic origin of the onset of pressure ulcers has been known for a long time, with the instruction given to carers to provide postural changes to patients every 2 to 4 hours (thus avoiding any cellular necrosis due to the absence of oxygen), it is only very recently that a purely mechanical origin to the onset of pressure ulcers has been discovered. Any soft tissue placed under normal pressure and/or shear can indeed become necrotic as a result of the mechanical deformation caused. And such necrosis can occur within minutes if the deformation is significant. In the case of pressure ulcers already formed in anatomical regions such as the heel or sacrum, the application of dressings is recommended to promote healing and protect the wound from external aggression. To our knowledge, little work has been done to study the protective role that these dressings could have from a mechanical point of view. It seems appropriate to reduce as much as possible the pressure exerted on the wound and on the soft tissues surrounding the wound. Of course, these pressures cannot be completely relieved when the skin and the dressing are in contact with a mattress-like support. However, it is to be hoped that the dressing will (1) absorb some of the mechanical energy from the contact and (2) distribute this pressure more evenly around the wound in areas less susceptible to the risk of cell necrosis. The aim of this research project is to simulate, with the help of a computer tool, the way in which the dressing will distribute the mechanical stresses of surface contact towards the wound and the surrounding soft tissues. For this purpose, biomechanical soft tissue modelling methods and numerical simulation tools will be used.
The most widely used mathematical method for modelling soft structures and for simulating their deformation is the "Finite Element Method" which consists of discretising the partial differential equations of the mechanics of continuous media. The TIMC-IMAG laboratory has thus developed numerous biomechanical models of the organs and soft tissues of the human body, including a model of the foot and a model of the gluteal region. During this research project, pressure ulcer geometries will have to be collected in order to modify these two models and simulate wounds in the heel and sacrum regions. A finite element model of the dressing will then be developed for application to the simulated wounds. This model should represent the different components of the dressing and the interactions between these components. The behavioural laws of these constituents will be estimated from uniaxial and bi-axial traction experiments carried out within URGO R.I.D. They will then be entered as parameters of the finite element model of the dressing, in interaction with the wound models included in the biomechanical models of the foot and gluteal soft tissues. Boundary conditions of pressure loading will then be simulated to quantify the protective effect of the dressing.
The ANSYS software platform will be used to model the coupling between dressing and pressure wound.

Skills

The desired candidate will have a background in biomechanics with knowledge of the finite element software ANSYS. He/she should be interested in the theoretical and experimental aspects related to the targeted application, with an interest in medical applications.

Work Context

The TIMC-IMAG host laboratory is a CNRS and Grenoble Alpes University laboratory located on La Tronche Health Site, just in front of the Grenoble Alpes University Hospital. It brings together nearly 300 people in twelve research teams focused on Health Technologies. The Bioméca-TIMC team (Biomechanics of Living Tissues and Materials - Modelling and Characterisation), which will host the post-doctoral student, is made up of about twenty people whose research themes relate to the biomechanical modelling of soft tissues and biomaterials.
The URGO company is the French leader in the field of wound dressings. As part of this post-doctorate, the company expects progress on the quantitative evaluation of the protective effect of its dressings.

Constraints and risks

Regular trips (on average one every two months) to the city of Dijon (URGO's headquarters) should be planned.

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