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Portail > Offres > Offre UMR5309-XAVLEG-003 - Poste post-doc (H/F) sur "le développement de nanoclusters métalliques atomiquement précis marqués sélectivement sur des protéines désordonnées pour des capacités de détection moléculaire".

Post-doc position (H/F) on “the development of atomically precise metal nanoclusters selectively labelled to disordered proteins for molecular sensing capabilities”

This offer is available in the following languages:
Français - Anglais

Date Limite Candidature : lundi 22 août 2022

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General information

Reference : UMR5309-XAVLEG-003
Workplace : LA TRONCHE
Date of publication : Monday, August 1, 2022
Type of Contract : FTC Scientist
Contract Period : 18 months
Expected date of employment : 1 December 2022
Proportion of work : Full time
Remuneration : 2712.12 to 3831.57 gross/ months depending on the experience
Desired level of education : PhD
Experience required : 1 to 4 years

Missions

Atomically precise metal (gold, silver, platinum) clusters represent a promising family of ultra-small theranostic agents for the diagnostic and the treatment of many diseases such as cancer, neurological or cardio-vascular pathologies. We recently demonstrated how generating assembly of gold nanoclusters (Au NCs) led to outstanding new photonic properties (ACS Nano 2016,10, 2591; Nanoscale 2019, 11, 12092).

In the NanoGold project funded by ANR, we intend to design multidimensional controlled assemblies of atomically precise AuNCs using intrinsically disordered proteins (IDPs) as matrix and to investigate the structural and photophysical properties of these new nanosystems with innovative advanced techniques. Creating these controlled assembly of AuNCs will pave the way to tailor new nanostructures for biophotonic applications and answer fundamental questions on the origin of their fluorescence.

Activities

In this purpose, one of the tasks of the NanoGold project relies on the synthesis and the functionalization of new AuNCs for selective bindings to IDPs with a deep investigation of their physico-chemical and optical properties as well as their detection in microfluidic devices and in cells by near infrared imaging (NIR-I (600-900 nm) /NIR-II (900-1700 nm)). The post-doctoral fellow might be involved also with collaborators in Montpellier (CBS) and in Lyon (ILM) on the structural investigation of these news nanostructures.

Skills

We are looking for a motivated and enthusiastic Post-doc that should have background in fields related to nanochemistry/biotechnology and spectroscopy. Skills in bioimaging will be a plus but is not mandatory.

Work Context

The candidate will work in a multidisciplinary environment with chemists, biologists and physical engineers. The work takes place at the Institute for Advanced Biosciences (IAB) for the biological part. The IAB is an internationally renowned institute in fundamental and translational biomedical research based in Grenoble (18 teams, 300 people, 5 technical platforms). The parts related to the synthesis will be performed at the Chemistry Department of the Molecular Department (University of Grenoble Alpes) located nearby in Grenoble (France).

Constraints and risks

No specific risks are expected in this position

Additional Information

ANR Nanogold

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