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Reference : UMR5306-RODANT-003
Workplace : VILLEURBANNE
Date of publication : Friday, September 10, 2021
Type of Contract : FTC Scientist
Contract Period : 24 months
Expected date of employment : 3 January 2022
Proportion of work : Full time
Remuneration : between 2150 and 3069€ net monthly depending on experience and excluding withholding tax
Desired level of education : PhD
Experience required : 1 to 4 years
A postdoctoral position is open at the “Institut Lumière Matière” in Lyon, France (iLM - Université Claude Bernard Lyon 1, CNRS) in the frame of the European project FET-OPEN ARIADNE “Redefining mass spectrometry – a breakthrough platform for real-time noninvasive breath analysis with single ion detection of intact viruses and bacteria and post-analysis molecular characterization” (see https://cordis.europa.eu/project/id/964553). The objective of the ARIADNE project is to develop a multiple-stage analytical platform based on multi-dimensional mass spectrometry instrumentation, and to perform direct and instant detection of intact virus particles in breath and in water. ARIADNE integrates state-of-the-art technological advancements in breath sampling and post-ionization methods as well as non-destructive ultra-high mass analysis of single bioparticles.
The postdoc hired at iLM-CNRS will be in charge of using our local expertise in charge detection mass spectrometry (CDMS) of large bioparticles. He/she will be responsible for the development and evaluation of the second generation CDMS system operated in stand-alone mode, analyzing viruses and bacteria using electrospray. Additional top-down analysis on single bioparticles will be executed in the CDMS system by multiphoton dissociation using a CO2 laser for producing high mass fragments.
The candidate should have a PhD in Physical-Chemistry or (Bio/Analytical)-Chemistry. He/she should be experienced in laser spectroscopy (action spectroscopy) and MS, in particular MS of protein complexes: an expertise in native-MS will be particularly appreciated. Experience in MS instrumentation is a significant plus. The candidate should be comfortable with biological (large proteins and assemblies) sample handling: purification, storage and preparation for native-MS and have a critical eye on the evaluation of the structural integrity of the systems.
A Research Institute at the LyonTech–la Doua campus
Joint research laboratory of the Université Claude Bernard Lyon 1 and the CNRS (UMR5306)
Located on the LyonTech-la Doua campus at the heart of the Greater Lyon Metropole and the Auvergne Rhône-Alpes region
Over 300 students, research, teaching and support staff
6 research themes
Excellence in Physics and Chemistry Research:
Light for shaping and characterising matter
Fabricating (nano)materials and studying their optical, electrical, mechanical, thermal and rheological properties
Experimental and theoretical multi-scale methods : from nanometer to meter length-scales; from attosecond to second time-scales
Interdisciplinary projects in Engineering, Biological, Health and Environmental Sciences
Constraints and risks
laser safety and aerosols.
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