Missions

Conduct, by adapting experimental conditions, a set of techniques (cell line culture, reconstructed epidermis, genotyping, RT-QPCR) to conduct experiments for the ENVOL program "Epidermis Neurone Vascularization On Digital Library"
This project is led by a public-private consortium of three partners: 1) LBTI CNRS/Université Lyon 1 2) ICARE; 3) MGA MedTech.
The objective of the ENVOL project is to propose, by the end of the project, a model of innervated reconstructed skin on a microfluidic chip intended for the screening of cosmetic and pharmaceutical compounds. Following submission and approval by regulatory bodies, this model will be used for biocompatibility testing of medical devices and chemicals (skin sensitization). The model will make it possible to: 1) combine three in vitro tests and/or the vivo tests currently required for the evaluation of chemicals and medical devices into a single test; 2) propose alternative methods to animals for this evaluation in the field of medical devices.

Activités

• Select, develop, and adapt protocols
• Manage and organize technical resources within the framework of a scientific project
• Ensure the application of health and safety principles and rules
• Use and present analysis results, ensuring their follow-up and quality
• Write experimental or study reports and technical notes
• Participate in the dissemination/promotion of results (publications, oral presentations, posters).

Compétences

Key skills: Cell biology, skin biology
Knowledge:
• Biology with in-depth knowledge of skin tissue and its study models
• Knowledge of skin innervation, vascularization, and immunity
• Health and safety regulations
• Legal and ethical framework
• Applied computer science
• English language: B1 to B2 (Common European Framework of Reference for Languages)

Operational skills:
• Implementing in vitro cellular and molecular biology techniques (skin tissue engineering)
• Using activity-specific software
• Designing experimental devices
• Prioritizing tasks and organizing activities, taking into account constraints and deadlines
• Writing scientific documents
• Manage relationships with local contacts (LBTI Lyon) and industrial partners involved in the project (ICARE and MGA Medtech)

Professional skills:
• Good interpersonal skills and aptitude for research work (rigor, scientific integrity, and reliability)
• Organize work, manage priorities, and meet deadlines (organizational skills)
• Inform, exchange information, and report to the project leader
• Respect the confidentiality of sensitive information and data
• Work as part of a team
• Possess good communication skills (oral/written) in French and English

Internal training on specific software will be provided to the successful candidate.

Contexte de travail

The LBTI laboratory (UMR5305) is supervised by the CNRS and UCBL1 University and is under the overall management of the CNRS. The LBTI is spread across three sites (IBCP-Gerland, Edouard Herriot Hospital, and Rockefeller Faculty) and brings together around 120 permanent and temporary staff, including researchers, teacher-researchers, doctoral students, post-docs, and technical staff (for more information: https://lbti.ibcp.fr).
The unit's research activities are organized around six research teams and two platforms. Research topics include the study of healthy and pathological tissues and the development of innovative therapeutic strategies with high potential for clinical applications.
The management and administrative departments are located on the Gerland campus in the IBCP building (access via Metro B station Stade de Gerland). The research laboratories are located at the three sites mentioned above.
The unit manages a budget of €2 million per year, including €1.7 million in external contracts (e.g., five CIFRE fellowships, 11 industrial contracts, six ANR grants, one European project, etc.).
The successful candidate will join the SKIN team at LBTI CNRS 5305, on the Lyon Gerland site, reporting directly to B Fromy and J Lamartine, co-leaders of this team, as part of the ENVOL scientific project.
The position is in a sector subject to the protection of scientific and technical potential (PPST) and therefore, in accordance with regulations, requires your arrival to be authorized by the competent authority of the MESR.

Le poste se situe dans un secteur relevant de la protection du potentiel scientifique et technique (PPST), et nécessite donc, conformément à la réglementation, que votre arrivée soit autorisée par l'autorité compétente du MESR.