Missions

The candidate will work as part of the ANR EARSCAPE project, which aims to identify and understand the factors that shape human auditory sensitivity in healthy populations living in contrasting environments. Using a multidisciplinary approach combining eco-acoustics, physiology of hearing, anthropology and population genomics, the aim of the project is to explore the interactions between environmental and genetic factors involved in the variability of auditory sensitivity and to shed light on the mechanisms of adaptation to the soundscape. As part of this project, the main task of the researcher will be to detect and characterise the genomic selection signatures potentially associated with hearing sensitivity in human populations exposed to contrasting acoustic environments.

Activités

● Carry out bioinformatics analyses in population genomics
● Carry out analyses of high-throughput sequencing data
● Develop pipelines for analysing selection signals
● Write scientific articles
● Take part in national and international scientific conferences

Compétences

Candidates must hold a PhD in population genomics, genetic anthropology or genomic bioinformatics. An interest or experience in the analysis of human population data, including anthropological, socio-cultural or demographic inference aspects, will be valued.

Professional skills
● Skills in DNA data analysis (illumina short-reads and possibly long-reads such as HiFi PacBio) ● Skills in population genomics and selection detection ● Skills in structural and functional annotation of eukaryotic genomes ● Skills in phylogenetic and evolutionary analyses of gene families ● Fundamental knowledge of population genomics and/or eco- evolutionary theories ● Interpretation and formatting of the results obtained (publications) ● Proficiency in programming languages (Bash, Python, R), code management tools and software environments (Gitlab, Conda, HPC-type computing clusters, etc.), as well as interfacing tools applied to genomics operating systems (workflow engine).

Interpersonal skills
● Language skills: very good level of English and communication skills ● Ability to work independently, communicate, and work in a team ● Open-minded: interest in evolutionary theories, genetic anthropology, genome analysis, etc. ● The researcher would ideally be motivated, curious and enthusiastic about working in a collaborative team, having close exchanges with bioinformaticians, analysts, and all the research teams involved in ANR EARSCAPE (mainly 2 sites: CRBE in Toulouse and Eco-Anthropologie unit in Paris).

Contexte de travail

The person recruited will be based at the Musée de l'Homme in Paris within the Eco-Anthropologie UMR 7206 unit (https://ecoanthropologie.fr/fr) and will interact regularly with the UMR5300 Centre de Recherche pour la Biodiversité et l'Environnement. The UMR 7206 is a multi-disciplinary unit whose staff (100 people) belong to six teams working in disciplines ranging from theoretical and applied population genetics to ethnology and ethnoecology, including primatology, human biodemography, biological anthropology, archaeoanthropology and linguistics. The successful candidate will work as part of the AGene team (https://ecoanthropologie.fr/fr/anthropologie-genetique-agene-6043), whose research focuses on three areas: (i) settlement history and inference of demographic processes, (ii) adaptation of human populations to their environment, and (iii) interactions between genetic and cultural processes in the human species.
She will interact mainly with B. Toupance and E. Heyer. The UMR5300 Centre de Recherche pour la Biodiversité et l'Environnement (Research Centre for Biodiversity and the Environment) is a research unit that studies the influence of the environment and environmental changes on living organisms, including humans, particularly through the One-Health approach. The person recruited will interact with the members of the evolutionary biology department, which is interested in understanding the evolutionary mechanisms acting on the genome and the consequences for phenotypic diversity, for a wide range of organisms. (https://crbe.cnrs.fr/departement-biologie-evolutive/ P. Balaresque, N. Brucato).

Contraintes et risques

NA