Researcher in cellular and molecular neurobiology: 'Mechanotransduction and signalling at individual synapses' (M/F)

Job Description

Missions

The candidate will lead a project exploring mechanotransduction and signalling at the level of individual synapses, investigating how multimodular adhesion complexes translate mechanical changes into specific signalling pathways, thereby linking structural and functional plasticity at the single-synapse level. Our aim is to elucidate the mechanobiological processes dependent on neural activity that regulate the composition and organisation of proteins within synapses. Although neural activity is recognised as a driver, via signalling pathways, of the remarkable molecular, structural and functional plasticity of synapses, the role of mechanical forces in this process is only just beginning to be revealed.

Activity

The researcher will utilise single-cell manipulations and state-of-the-art imaging techniques in acute and organotypic brain slices, as well as in dissociated neuronal cultures. The candidate will combine innovative methodologies at the intersection of cellular neurobiology on brain slices, molecular mechanobiology, chemobiology and super-resolution imaging (including super-resolution and expansion microscopy), as well as advanced signalling imaging techniques (fluorescence lifetime, FRET biosensors and calcium imaging).

Your Profil

Skills

We are seeking a motivated candidate with a keen interest in neuroscience and cellular mechanobiology, and in understanding these fields at the cellular and molecular levels. The candidate must have solid experience in the preparation, culture, transfection and advanced imaging of brain slices (mouse, rat). The candidate must be familiar with signalling imaging techniques (fluorescence lifetime, FRET biosensors and calcium imaging). Proficiency in scientific software tools for image and data analysis is a prerequisite. The candidate must hold a PhD in neuroscience or cell biology (awarded within the last 3 years) and possess good oral and written communication skills in English.

Your Work Environment

Established on 1 January 2011, the Interdisciplinary Institute of Neurosciences (IINS) is a joint research unit affiliated with the CNRS and the University of Bordeaux. With a staff of 170 people divided into 12 teams, the IINS brings together multidisciplinary expertise to study the molecular and cellular mechanisms involved in brain activity. The Institute develops innovative methods in imaging, chemistry, physiology and computing. As part of Bordeaux Neurocampus, the IINS is one of the leading players in the neuroscience community in Aquitaine.

Constraints and risks

Possibility of working shift hours

Compensation and benefits

Compensation

Between €3,041 and €4,216 gross per month, depending on experience

Annual leave and RTT

44 jours

Remote Working practice and compensation

Pratique et indemnisation du TT

Transport

Prise en charge à 75% du coût et forfait mobilité durable jusqu’à 300€

About the offer

About the CNRS

The CNRS is a major player in fundamental research on a global scale. The CNRS is the only French organization active in all scientific fields. Its unique position as a multi-specialist allows it to bring together different disciplines to address the most important challenges of the contemporary world, in connection with the actors of change.

CNRS

The research professions