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Portail > Offres > Offre UMR5297-MELDES0-200 - Chercheur en neurosciences "Ingénierie et détermination de la structure des complexes protéine-récepteur neuronaux importants pour la neurotransmission" H/F

Neuroscience researcher "Engineering and structure determination of neuronal protein-receptor complexes important for neurotransmission" M/F

This offer is available in the following languages:
- Français-- Anglais

Date Limite Candidature : jeudi 29 février 2024

Assurez-vous que votre profil candidat soit correctement renseigné avant de postuler

Informations générales

Intitulé de l'offre : Neuroscience researcher "Engineering and structure determination of neuronal protein-receptor complexes important for neurotransmission" M/F (H/F)
Référence : UMR5297-MELDES0-200
Nombre de Postes : 1
Lieu de travail : BORDEAUX
Date de publication : jeudi 8 février 2024
Type de contrat : CDD Scientifique
Durée du contrat : 18 mois
Date d'embauche prévue : 1 mars 2024
Quotité de travail : Temps complet
Rémunération : Entre 2905.76 et 3331.51€ brut selon expérience
Niveau d'études souhaité : Niveau 8 - (Doctorat)
Expérience souhaitée : Indifférent
Section(s) CN : Molecular and cellular neurobiology, neurophysiology


The project will focus on engineering and structure determination of neuronal protein-receptor complexes that are important for neurotransmission.

The project is already in an advanced stage, which means that the candidate will be able to build quickly on a significant body of existing results


The work will involve protein production from mammalian cells, protein purification and protein chemistry, biophysical interaction analysis (SPR, BLI), engineering of protein-protein interactions, and structure determination using X-ray crystallography and cryo-EM.


The candidate must hold a PhD degree and have less than seven years of post-doctoral experience at the start of the contract. The candidate should have a solid background in molecular biology, biochemistry and/or structural biology. Experience with (i) mammalian expression systems (HEK293 cell lines), (ii) biophysical analysis methods (surface plasmon resonance, isothermal titration calorimetry, microscale thermophoresis, bio-layer interferometry, etc.), and (iii) X-ray crystallography or cryo-EM, is preferred. The candidate should be highly motivated, a team player, and have a can-do problem-solving attitude.

Contexte de travail

Created on January 1, 2011, the Institut interdisciplinaire de neurosciences (IINS) is a joint research unit attached to the CNRS and the University of Bordeaux. With 170 staff in 14 teams, IINS combines multidisciplinary skills to study the molecular and cellular mechanisms involved in brain activity. The Institute develops innovative methods in imaging, chemistry, physiology and computer science. A component of Bordeaux Neurocampus, IINS is one of the major players in the neuroscience community in Aquitaine.
This is a full-time position. The project will be carried out under the supervision and mentorship of Dr. Jonathan Elegheert.

Contraintes et risques

Possibility of working shifts