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Portal > Offres > Offre UMR5288-MARSOU-003 - Chercheur "H/F" en analyse bio-informatique de donnees paléogénomiques

Post-doctoral researcher in bio-informatics and ancient genomics

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Français - Anglais

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General information

Reference : UMR5288-MARSOU-003
Workplace : TOULOUSE
Date of publication : Monday, June 22, 2020
Type of Contract : FTC Scientist
Contract Period : 24 months
Expected date of employment : 1 October 2020
Proportion of work : Full time
Remuneration : Monthly gross salary between 2617 and 4150 euros, depending on documented experience
Desired level of education : PhD
Experience required : Indifferent

Missions

The project is part of the ERC funded PEGASUS programme (http://orlandoludovic.wixsite.com/pegasus-erc). It is aimed at reconstructing the domestication history of the horse, and other equine species in general, from their early domestication stages to their most recent intensive selection that accompanied the emergence of modern breeds.

The project builds on genomic and epigenomic data gathered from almost 1,000 ancient horse, mule and donkey specimens spread across the Old World and the last six millennia. Such extensive (epi)genomic time series are designed to identify the list of genetic and epigenetic changes that have accompanied the transformation of wild animals into a diversity of domestic forms, and assess the presence of potential management differences across ancient past civilisations, including selection and admixture.

The main genetic and epigenetic results will provide the basis to assess the validity of a number of archaeological hypotheses and will be enriched by the information provided by other historical sources, including coinage, texts and art.

Activities

The succesful application will dedicate his/her time to perform research and publish the results of his/her work, within the framework of the international programme PEGASUS.

S/he will carry out bio-informatic analyses aimed at addressing the main questions of the programme, building on the extensive (epi)genomic time series already collected in the laboratory.


S/he will implement analyses aimed at listing the genetic and epigenetic changes that have accompanied the transformation of wild animals into a diversity of domestic forms, and assessing the presence of potential management differences across ancient past civilisations, including selection and admixture.

S/he will take an active role in the organisation of annual meetings and/or workshops aimed at updating our international collaborators with our latest findings.

S/he will be expected to play an active role in the preparation of the articles presenting his/her results.

Skills

Applicants will hold a PhD diploma in evolutionary genomics.

S/he will master one computational language or more, and will be able to develop innovative bio-informatic packages leveraging population genetic tools and aimed at eg reconstructing population evolutionary histories and detecting selection signatures.

S/he will show a strong expertise in population genetics, especially in the bio-informatic analysis of collections of genomes characterized at the population scale using Illumina next-generation sequencing instruments.

S/he will demonstrate excellent scientific productivity, documented by a strong publication record.

S/he will able to work in an international environment and a team including researchers from across the whole world. S/he will communicate in English.

First-hand experience in the analysis of ancient DNA data - with practical knowledge of their advantages and limitations - or in the equine genomic science will be considered favorably.

Work Context

This project is part of the ERC-funded PEGASUS programme (ERC CoG agreement n° : 681605 ; http://orlandoludovic.wixsite.com/pegasus-erc) and an international team of 20+ researchers.

The PEGASUS programme (2016-2021) is broadly focused on the history of horse domestication and is built around three main work packages:

1. Assessing the (epi)genomic transformation and the changes in the oral microbiome that have accompanied early domestication stages;

2. Assessing the impact of emerging equestrian techologies and how they have remodeled the horse genome and their physiology and behavior;

3. Assessing the impact of various husbandry practices on the horse (epi)genome, from those implemented in the early domestication stages to those that involved extreme articial selection and propelled the emergence of hundreds of modern breeds.


The PEGASUS programme is hosted at the AMIS laboratory, within the AGES research team (Archaeology, Genomics, Evolution and Societies). The AMIS laboratory is affiliated at CNRS and the University Paul Sabatier (Toulouse III) and is located in the city centre, at the Purpan Medical School. The laboratory hosts a staff of 75+ lab technicians, students, researchers and professors, 30 of which on permanent contracts. The laboratory expertise is within the fields of evolutionary genomics, ancient DNA, anthropology and evolutionary medicine.

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