Missions

As part of an industrial chair between Orano and the Lyon Cancer Research Centre, we are looking for a postdoctoral researcher in organic chemistry for a 12- to 18-month contract. The position will be based at the Lyon Est Faculty of Medicine (Rockefeller site). Currently booming, internal vectorised radiotherapy involves vectorising radionuclides as close as possible to cancer cells in order to destroy them. This vectorisation is generally carried out by a biomolecule (peptide, antibody, oligonucleotide, etc.) capable of binding specifically to a tumour biomarker. As the majority of radionuclides used in medicine are metals, their binding to the biomolecule relies on a chelating agent, which is usually covalently bound to the biomolecule. This chelating agent must be able to complex the radiometal rapidly and stably under physiological conditions (low concentration, pH, temperature, aqueous phase, etc.). In addition, the chelator must have a reactive function to enable it to bind to the biomolecule (bifunctional chelator). For each metal, it is therefore necessary to develop a specific chelator in order to optimise the performance of the radiopharmaceutical. The synthesis and optimisation of these chelators is therefore the first step in the development of effective internal vectorised radiotherapy.

Activités

Under the supervision of Prof. Marc Le Borgne and in close partnership with Dr. Benjamin Gibert's team and industrial partner Orano, the candidate will be responsible for: - Synthesising a series of bifunctional chelators using previously described synthesis routes. - Optimising existing synthesis routes to facilitate synthesis/improve yields. - Developing the synthesis of new chelating agents. - Developing procedures for the bioconjugation of bifunctional chelating agents with biomolecules. Fixed-term contract of 12 to 18 months.

Compétences

Profile: Minimum 8 years of higher education Education: - PhD in organic chemistry, medicinal chemistry or coordination chemistry, ideally at the interface between chemistry and biology Skills: - Mastery of techniques: Organic synthesis, purification techniques (chromatography, HPLC, etc.), characterisation techniques (CCM, HPLC, LC-MS, NMR, etc.). - Optional: cell culture, animal experimentation, radiochemistry, manual and/or automatic peptide synthesis. - Development and implementation of syntheses. - Characterisation of intermediates and final compounds (1H/13C NMR, LC-MS, etc.). - Ability to analyse and statistically interpret experimental results. - Scientific communication. - Participation in the life of the centre. Proficiency in software: Office Suite, MestreNova or equivalent, Chemoffice, MassHunter or equivalent.

Contexte de travail

The postdoctoral researcher will work in the 'Gastroenterology and Health Technologies' team at the Lyon Cancer Research Centre (CRCL). This is a research team composed of 20 members (10 students, researchers, postdocs, research engineers) and benefits from an appropriate level of funding. The CRCL offers a rich scientific environment focused on cancer biology with 24 research teams and several cutting-edge technology platforms. For more information, visit http://www.crcl.fr/.

Contraintes et risques

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Informations complémentaires

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