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Portail > Offres > Offre UMR5255-CHLGRA-002 - Post-doctorat (H/F): Biosenseurs à base de nanoparticules fluorescentes

Post-doctorate (M/W): synthesis of fluorescent polymer nanoparticles

This offer is available in the following languages:
- Français-- Anglais

Date Limite Candidature : mercredi 13 mars 2024

Assurez-vous que votre profil candidat soit correctement renseigné avant de postuler

Informations générales

Intitulé de l'offre : Post-doctorate (M/W): synthesis of fluorescent polymer nanoparticles (H/F)
Référence : UMR5255-CHLGRA-002
Nombre de Postes : 1
Lieu de travail : TALENCE
Date de publication : mercredi 10 janvier 2024
Type de contrat : CDD Scientifique
Durée du contrat : 12 mois
Date d'embauche prévue : 1 février 2024
Quotité de travail : Temps complet
Rémunération : Between €2905 and €4081 gross per month, depending on experience
Niveau d'études souhaité : Niveau 8 - (Doctorat)
Expérience souhaitée : Indifférent
Section(s) CN : Supra and macromolecular materials and systems: development, properties, functions

Missions

Functional fluorescent nanoparticles (NPs) used in the biomedical field are traditionally obtained in two steps: first a hydrophobic fluorescent nanoparticle is synthesized, then a targeting agent is introduced via a grafting step. The challenge is to synthesize these NPs in a single step using amphiphilic block copolymers. With this in mind, the project aims to prepare NPs whose shellis based on a hydrophilic biomacromolecule (DNA, protein, etc.), while the core is made of a hydrophobic polymer doped with fluorescent dyes. NPs are formed by assembling amphiphilic copolymers. The fluorescent properties of the NPs will be studied, as well as their suitability for use as biosensors or biomarkers. The contract is due to start between January and March 2024, and is renewable.

Activités

- synthesis of fluorophores and polymers, grafting
- characterization of amphiphilic copolymers
- characterization of nanoparticles (DLS, TEM)
- spectroscopic characterizations
- possibly biological imaging and/or evaluation of fluorescent objects as biosensors

Compétences

- heterocycle synthesis
- polymer or macromolecule characterization
- physics/physical chemistry/nanoscience knowledge

Contexte de travail

The post-doctorate is part of the ERC COMET program (2023-2028 https://cordis.europa.eu/project/id/101077364/fr) and is based at the Institut des Sciences Moléculaires (ISM). The ISM brings together a community of organic and physical-chemical researchers interested in molecular buildings, and working on their design, synthesis, characterization, reactivity and analysis in various environments. The ISM is a CNRS / Université de Bordeaux / Bordeaux INP Aquitaine Joint Research Unit (ISM, UMR 5255 CNRS) reporting to the Délégation Régionale Aquitaine (DR 15). The Institute's expertise is built around a number of core competencies: - theorists in quantum chemistry and molecular and reaction dynamics, - synthetic organic chemists, - physical-chemical experimenters (spectroscopy, photochemistry, molecular recognition and analysis). This multidisciplinary range of skills enables us to develop research projects on cross-disciplinary themes within the Institute: surfaces, interfaces and materials, nanosciences, green chemistry and catalysis, natural and bioactive molecules, modeling. The thesis will be carried out as part of the IPM/LAGON team, whose areas of research focus on : - Molecular photonics: functional molecules and molecular assemblies (design, optical and non-linear optical properties). - Multiphotonics - Development of nano-sized platforms (nanoparticles, nanodots, etc.), -Photo-active nano-objects for therapy and delivery of bioactive molecules - Glycochimie et chimie bio-orthogonale

Le poste se situe dans un secteur relevant de la protection du potentiel scientifique et technique (PPST), et nécessite donc, conformément à la réglementation, que votre arrivée soit autorisée par l'autorité compétente du MESR.