Informations générales
Intitulé de l'offre : Postdoc in biophysics and structural biology of amyloids (ERC supported) : molecular basis of taupathies (M/F) (H/F)
Référence : UMR5248-YANFIC-011
Nombre de Postes : 1
Lieu de travail : PESSAC
Date de publication : mercredi 12 mars 2025
Type de contrat : Chercheur en contrat CDD
Durée du contrat : 24 mois
Date d'embauche prévue : 15 mai 2025
Quotité de travail : Complet
Rémunération : 2991 - 4166 €
Niveau d'études souhaité : Doctorat
Expérience souhaitée : 1 à 4 années
Section(s) CN : 16 - Chimie du vivant et pour le vivant : conception et propriétés de molécules d'intérêt biologique
Missions
Amyloid aggregates are highly ordered protein assemblies that can be both functional and pathogenic. The intrinsically disordered protein called tau is directly implicated in several neurodegenerative diseases, including Alzheimer's disease, where it forms amyloid aggregates. In these diseases, called tauopathies, tau can adopt different conformations, which are directly correlated with the pathological phenotype. Yet, to date, the challenge of understanding what dictates the structural differentiation of tau has remained unmet.
Activités
Our group studies the formation of tau aggregates and more generally the molecular basis of tauopathies. This project aims at characterizing tau aggregation pathways leading to the formation of specific tau assemblies that recapitulate brain-extracted properties (structure, seeding, etc...). The position will focus on revealing the influence of different biomolecules on the biophysical and structural features of tau amyloids. The position is part of an ERC startup project “CofacTau” held by Dr. Yann Fichou.. Please get in touch with Yann for more information (y.fichou@iecb.u-bordeaux.fr)
Compétences
We are looking for a highly motivated candidate seeking to expend their research experience. The ideal candidate will have a strong background in structural biology, in particular cryoEM or/and NMR spectroscopy applied to amyloids. This is a great opportunity to embrace a multidisciplinary project combining biochemistry, biophysics and structural biology. The successful candidate will be independent and thrive in a small and synergetic team.
Contexte de travail
The position will take place at the CBMN Laboratory (UMR5248) in the team of Y. Fichou (www.fichou-lab.cnrs.fr), located at the European Institute of Chemistry and Biology (IECB) near Bordeaux. The IECB is a multidisciplinary institute at the interface of biology and chemistry, and is equipped with several platforms (biochemistry, bacteriology, crystallography, NMR, cryo-electron microscopy) that will be accessible during the postdoctoral project.
Contraintes et risques
none