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Reference : UMR5248-CHRDOL-001
Workplace : PESSAC
Date of publication : Thursday, January 09, 2020
Type of Contract : FTC Scientist
Contract Period : 12 months
Expected date of employment : 17 February 2020
Proportion of work : Full time
Remuneration : 2600 - 3300 € gross monthly according to experience
Desired level of education : PhD
Experience required : Indifferent
This project aims at developing foldamer-based approaches for mimicking multi-stranded β-sheet architectures encountered in proteins, in particular β barrels. Preliminary studies have shown the ability to design and synthesize sequence-specific synthetic oligomers that fold into well-defined β-sheet secondary structures (i.e. foldamers), akin to those found in proteins, making it now possible to envisage the de novo design of more complex multi-stranded artificial β-sheet architectures. The objective of this project is to build molecules designed to fold rationally into β-barrel by forming intramolecular hydrogen bonds, using a combination of "artificial β-strand" and "β-turn mimic" motifs. Functionalization will then be considered in order to modulate their solubility, give them surface or substrate recognition properties, and study their self-assembly properties.
- Synthetic Organic Chemistry including solid-phase synthesis
- Structural analysis in solution and in the solid state
PhD in synthetic organic chemistry and/or peptide chemistry with a strong background in supramolecular chemistry.
We are seeking for highly motivated and talented candidates. Applicants with excellent records will be given priority.
CBMN and IECB (http://www.iecb.u-bordeaux.fr/) are dynamic interdisciplinary research centers located on the campus of the University of Bordeaux, France. The laboratory is perfectly equipped for chemical synthesis and the institute is equipped with technology platforms bringing the state-of-the-art scientific instrumentation and expertise in structural biology and preparative and analytical techniques.
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