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Portail > Offres > Offre UMR5247-NICFLO-002 - contrat Post-Doc en modélisation moléculaire (F/H) (H/F)

Post-doc position in molecular modelling (H/F)

This offer is available in the following languages:
Français - Anglais

Date Limite Candidature : jeudi 1 décembre 2022

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General information

Reference : UMR5247-NICFLO-002
Workplace : MONTPELLIER
Date of publication : Thursday, November 10, 2022
Type of Contract : FTC Scientist
Contract Period : 18 months
Expected date of employment : 1 February 2023
Proportion of work : Full time
Remuneration : between 2833€ and 3257€ brut / month
Desired level of education : PhD
Experience required : 1 to 4 years

Missions

G-Protein Coupled Receptors (GPCRs) form a large family of membrane proteins that constitute key privileged targets for the design of new drugs. Despite a large set of available structures, their regulation mechanism at the molecular scale still requires to be characterized. This is principally due to the fact that this mechanism involves the modulation by different partners (ligands, lipids, ions, intra-cellular effectors, etc...) of the equilibria between different intrinsic conformations, some features that are hard to be captured by structural methods. Things are even more complicated if we consider homo- or hetero-dimers of GPCRs. Only a few structures in the PDB describe the possible orientation of GPCR protomers in such assemblies. Some years ago, we proposed a model of the Ghrelin:Dopamin hetero-dimer in which each receptor was bound to its favorite G-protein partner at the same time. This model was experimentally validated by the measurement of crossed distances between the two receptors and the two G-proteins. Thanks to the “Grand Challenge” phase on the Jean-Zay machine provided by GENCI, we already performed extensive simulations of this dimeric model and its isolated entities. The objective of these simulations is to understand the cross-talk that
operates in such large molecular assemblies and help to the design of new potent ligands.
We propose here an 18 months contract, funded by FRM (foundation pour la recherche médicale) for a highly motivated post-doctoral fellow, ideally beginning in January 2023.

Activities

The objective of the recruited post-doc will be to analyze the already obtained data and run complementary molecular dynamics simulations to provide a global mechanical view of how these complex systems behave at the membrane surface. The work will be performed in close collaboration with experimentalists in the laboratory, including biochemists and chemists for validation purposes. This collaboration could include the production of protein variants and the synthesis/testing of new ligands.

Skills

The seeked candidate would ideally have a good experience in running / analyzing molecular dynamics simulations of peptides and proteins, and a validated PhD in a related field. She/He will have good knowledge of classical force-fields and MD codes and especially Gromacs; a plus would be to already have practiced coarse-grained force-fields (MARTINI FF). The candidate must be autonomous under the linux environment, and know at least one scripting language to analyze all produced data (python, R, etc ...). The candidate must be fluent in English and able to present her/his results either to specialists or non-specialists.

Work Context

The candidate will join the IBMM F13 Team entitled 'cellular pharmacology' working in the modelling group (N. FLOQUET) in the new building of pole chimie balard (campus CNRS) route de mende, Montpellier, France.

Constraints and risks

No identified risk

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