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Portal > Offres > Offre UMR5247-MORJOL-004 - Post-doc IBMM Montpellier 2020 PEPTIDE-BASED SUPRAMOLECULAR POLYMERS (H/F)

Post-doc IBMM Montpellier 2020 PHOTO-SWITCHABLE SUPRAMOLECULAR POLYMERS

This offer is available in the following languages:
Français - Anglais

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General information

Reference : UMR5247-MORJOL-004
Workplace : MONTPELLIER
Date of publication : Wednesday, December 11, 2019
Type of Contract : FTC Scientist
Contract Period : 12 months
Expected date of employment : 1 February 2020
Proportion of work : Full time
Remuneration : 2400-2800 € per month
Desired level of education : PhD
Experience required : 1 to 4 years

Missions

The Self-Assembly of BioMaterials (SelfBioMat) project aims at developing peptide-based supramolecular polymers as biomaterials which are self-assembled in a hierarchical manner by the smart combination of dynamic covalent chemistry and supramolecular chemistry. The work will involve the synthesis of building blocks – aromatics and modified peptides, the characterization of the supramolecular self-assembly, and the detailed study of the mechanism of supramolecular polymerization.

Activities

The work will involve the synthesis, purification, and characterization of aromatic and peptide building blocks, the characterization of the supramolecular self-assembly (UV-Vis, Fluo, CD spectroscopies et TEM, AFM microscopies), and the detailed study of the mechanism of supramolecular polymerization.

Skills

We are looking for a highly motivated candidate. You have a Ph.D. – or will have defended your thesis prior to taking up the position – in (bio)organic/peptide chemistry and/or supramolecular chemistry and have demonstrated your ability to carry out cutting-edge research projects. You have solid laboratory skills in organic chemistry and characterization techniques (NMR, MS, HPLC). You have basic knowledge in the area of supramolecular polymers. You are a team player with excellent communication skills and are fluent in English. Knowledge of French would be useful but is not required.

Work Context

Our research is oriented toward the design and application of adaptive and responsive biomolecular self-assemblies, with for instance further developments as smart artificial vectors for gene delivery.[1] We have hitherto reported on the use of dynamic covalent chemistry for the dynamic expression of different types of architectures that promote nucleic acids recognition and delivery: dynamic covalent polymers,[2] peptide clusters,[3] and metallo-supramolecular complexes.[4]
[1] a) S. Ulrich, Acc. Chem. Res., 2019, 52, 510-519 ; b) E. Bartolami, C. Bouillon, P. Dumy, S. Ulrich, Chem. Commun., 2016, 52, 4257-4273; [2] a) C. Bouillon, Y. Bessin, F. Poncet, M. Gary-Bobo, P. Dumy, M. Barboiu, N. Bettache, S. Ulrich, J. Mater. Chem. B, 2018, 6, 7239-7246 ; b) C. Bouillon, D. Paolantoni, J. C. Rote, Y. Bessin, L. W. Peterson, P. Dumy, S. Ulrich, Chem. Eur. J., 2014, 20, 14705-14714; [3] a) E. Bartolami, Y. Bessin, V. Gervais, P. Dumy, S. Ulrich, Angew. Chem. Int. Ed., 2015, 54, 10183-10187 ; b) E. Bartolami, Y. Bessin, N. Bettache, M. Gary-Bobo, M. Garcia, P. Dumy, S. Ulrich, Org. Biomol. Chem., 2015, 13, 9427-9438; [4] a) W. Drozdz, A. Walczak, Y. Bessin, V. Gervais, X. Y. Cao, J. M. Lehn, S. Ulrich, A. R. Stefankiewicz, Chem. Eur. J., 2018, 24, 10802-10811 ; b) W. Drożdż, Y. Bessin, V. Gervais, X.-Y. Cao, J.-M. Lehn, A. R. Stefankiewicz, S. Ulrich, Chem. Eur. J., 2018, 24, 1518-1521.

Constraints and risks

Protection to LED irradiation will be provided.

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