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Reference : UMR5247-FRADEB-004
Workplace : MONTPELLIER
Date of publication : Tuesday, December 08, 2020
Type of Contract : FTC Scientist
Contract Period : 12 months
Expected date of employment : 1 February 2021
Proportion of work : Full time
Remuneration : 2675 € gross monthly
Desired level of education : PhD
Experience required : Indifferent
12-months Post-doctoral contract from February 2021.
The candidate will work in the GAVO - Generation of Original Antivirals research program bringing together a consortium of 4 organic chemistry laboratories specializing in the synthesis of nucleosides and nucleic acids. The project aims to build libraries of molecules with antiviral activity with an original and modular structure.
The ongoing COVID-19 pandemic caused by SARS-CoV-2 highligths the need for a collection of effective and selective antivirals, directly scalable to be quickly targeted to emerging pathogens. It should also be remembered that there is currently no specific treatment for human Coronavirus infections. Over the years, nucleoside analogs have become powerful therapeutic agents for the treatment of viral infectious diseases.
In this context, the synthesis of nucleosides modified on the sugar moiety, on the heterocyclic part or at the glycosidic bond will be the main objective of this research work.
- Organic Synthesis of novel molecules
- Bibliography Search
- Design of modified nucleosides
- Publications writing
- Resultats presentation
The candidate should have a PhD degree in organic chemistry. The ideal candidate for this project will have to demonstrate a solid experience in organic synthesis, including modern tools of organic chemistry and experience in chemistry of nucleosides and nucleic acids will be an advantage.
In addition, the candidate should have qualities in terms of communication (collaborative work within the consortium), good team spirit and skills in report writing and presentation of results.
The post-doctoral fellow will work in the ChemBioNAC team, directed by Prof. M. Smietana, part of IBMM (UMR5247, CNRS, UM, ENSCM, Dir. P. Dumy). This team mainly develops projects on nucleosides and nucleic acids (chemistry, chemical biology). It is housed in a building of the Campus Triolet of the University of Montpellier but its move to a new building on the CNRS campus is scheduled for mid-2021. This new building will bring together all the chemists at Montpellier and will house around 800 people with the facilitated interactions between institutes and teams that may result.
The ChemBioNAC team is composed of 1 Professor (UM), 3 Research Directors (CNRS, Inserm), 1 Research Associate (CNRS), 2 Assistant-professors (UM), 1 Research Engineer (CNRS), 1 Assistant- Engineer (CNRS). In addition to the permanent staff, the team also hosts 1 post-doc, 3 doctoral students, 1 fixed-term engineer, 2 Master 2 and several Master 1 students.
The researcher will work under the supervision of the project managers (Drs. J.-J Vasseur and F. Debart) already involved in the fight against emerging viruses for several years through collaborations. The post-doctoral fellow will have to work with doctoral students also working on antiviral research.
The strengths of the ChemBioNAC team are based on the complementarity of skills (chemistry of nucleosides, oligonucleotides, functionalization, conjugation, DNA catalysis) within the team, the international recognition of the group with numerous academic and industrial collaborations, the high level of its scientific production.
The team is attractive to future young researchers wishing to apply for CR competitions at the CNRS or MCU thanks to the expertise recognized in France and abroad in the chemistry of nucleic acids which find many applications as tools for biologists, virologists.
Constraints and risks
Usual safety rules for practicing organic chemistry.
Training in specific laboratory rules will be provided by the Health and Safety Engineer.
Rules of good conduct and practice to face COVID-19
The application must include the following elements:
- A detailed CV including at least two references, people likely to be contacted.
- A summary of past research experiences
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