Missions

Investigate the B. Fragilis Type 6 Secretion System using integrative structural determination and protein design approaches.

Activités

Integration of cross-linking mass-spectrometry data, cryoEM, and AlphaFold2 structures to construct comprehensive models of the B. Fragilis T6SS membrane complex.

Designing peptidic T6SS inhibitors to regulate the assembly and modulate the secretion activity.

Compétences

The ideal candidate should have a background primarily in biophysics of macromolecules or bioinformatics, with knowledge in one or more of the following domains: statistics, computer science, statistical mechanics, chemistry, molecular biology, or cell biology. Proficiency in molecular dynamics and/or machine learning is highly valued. Strong programming skills in Python are essential, as well as experience working on UNIX systems and computer clusters. Fluency in both spoken and written English is required. The ability to work effectively in a team and collaborate with experimentalists is also a necessity.

Contexte de travail

The research will be conducted at the Laboratoire de Biologie et Modélisation de la Cellule (LBMC), a research institute situated on the campus of the Ecole Normale Supérieure (ENS) in Lyon. The postdoctoral position will be part of the Dynamics and Control of Biological Assemblies and Macromolecular Machines team, within the framework of the ANR Cameleon project. The project will be supervised by Riccardo Pellarin, Paulo Telles de Souza, and Juliette Martin, and will involve collaboration with teams led by Eric Durand (IMM Marseille), Eduardo Rocha (Institut Pasteur Paris), Florian Stengel (University of Konstanz), and Ben Ross (Dartmouth School of Medicine).