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Reference : UMR5239-ISASER-009
Workplace : LYON 07
Date of publication : Friday, January 31, 2020
Type of Contract : FTC Scientist
Contract Period : 12 months
Expected date of employment : 1 April 2020
Proportion of work : Full time
Remuneration : bet. 2 640 and 2 750 gross monthly
Desired level of education : PhD
Experience required : Indifferent
The applicant is expected to work independently on fundamental problems relating to the mechanism of homologous recombination in the model organism S. cerevisiae. He/She will formulate hypothesis, design and perform experiments, and analyze the data he/she will generate.
• Hypothesis formulation and experimental design
• Molecular genetics in S. cerevisiae
• High throughput genomic assays
• Data analysis
• Bibliographic work
• Dissemination of the research output
Candidates should be highly motivated and be willing to take on intellectual, scientific and technical challenges. Preference will be given to candidates with less than three years of experience after his/her Ph.D. The following qualities are expected:
• Expertise in S. cerevisiae molecular genetics.
• Bioinformatics skills for analysis of large biological datasets (Python, R or other common programming language).
• Expertise in the field of DNA replication, repair and recombination is welcomed.
• Skills in protein biochemistry or live microscopy is a plus.
The laboratory will start on April 1st 2020 at the fully renovated Laboratory of Biology and Modelling of the Cell (LBMC) in the privileged environment of the Ecole Normale Superieure (ENS) campus in Lyon. It is supported by a generous ERC funding, and extension of the contract for a duration of up to 5 years is possible.
The project aims at tackling the as-yet mysterious mechanism of homology search that takes place during the repair of DNA double-strand break (DSB) by homologous recombination. The desired output of this project is an integrated and quantitative framework of homology search in cells, by using a complementary cycle between experiments in S. cerevisiae and computer simulations. The experimental systems and methodologies are readily available in the laboratory (including novel assays that enable to track early recombination intermediates in cells) and ample preliminary results have been gathered making this project immediately fun, and low risk/high gain.
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