Postdoctoral Fellow (M/F) in Electrophysiology and Molecular Pharmacology
New
- Researcher in FTC
- 24 months
- Doctorate
This offer is available in English version
This offer is open to people with a document recognizing their status as a disabled worker.
Offer at a glance
The Unit
Institut de génomique fonctionnelle
Contract Type
Researcher in FTC
Working hHours
Full Time
Workplace
34094 MONTPELLIER
Contract Duration
24 months
Date of Hire
01/01/2027
Remuneration
From €3,071 gross per month, subject to adjustment based on experience
Apply Application Deadline : 27 October 2026 23:59
Job Description
Missions
This open position is part of the French ANR “Target-Cav3” project. The successful candidate will be in charge of 1) characterizing the electrophysiological and pharmacological properties of disease variants of Cav3 calcium channels (Cav3.1), 2) studying the structure-activity relationships of these properties, and 3) characterizing existing and new ligands that modulate these channels and may be of potential interest for the treatment of diseases associated with gain-of-function variants of Cav3 channels.
Activity
Perform electrophysiological studies, using both manual and automated patch-clamp techniques, to investigate the gating properties (activation-inactivation processes) of Cav3 channel variants.
Characterize, using an electro-pharmacological patch-clamp approach, the sensitivity of these variants to Cav3 channel modulators.
Design and characterize a collection of Cav3 channel mutants to elucidate the gating mechanism and pharmacological sensitivity of Cav3 channels.
Implement functional and structural modeling approaches to interpret experimental observations.
Your Profil
Skills
Expert mastering of patch-clamp electrophysiological recordings of ion channels and analysis of electrophysiological data (experience gained during the PhD).
Skills in cell culture and transfection techniques.
Skills in computational modeling techniques.
Excellent ability to communicate about science and findings, analyze the literature, work independently, and collaborate as part of a team.
Your Work Environment
The project will be conducted at the Institute of Functional Genomics (IGF) within a team recognized worldwide for its work on Cav3 calcium channels and the study of calcium channelopathies. The successful candidate will benefit from the multidisciplinary expertise of the team and the Institute. More specifically, the project will be developed in close partnership with another IGF team specializing in molecular simulations of membrane proteins and AI-assisted pharmacology.
Constraints and risks
There are no specific requirements or risks.
Requested information : Please provide a detailed CV, a cover letter (related to the proposed project), and two references to be contacted.
Compensation and benefits
Compensation
From €3,071 gross per month, subject to adjustment based on experience
Annual leave and RTT
44 jours
Remote Working practice and compensation
Pratique et indemnisation du TT
Transport
Prise en charge à 75% du coût et forfait mobilité durable jusqu’à 300€
About the offer
| Offer reference | UMR5203-PHILOR-001 |
|---|---|
| CN Section(s) / Research Area | Molecular and cellular neurobiology, neurophysiology |
About the CNRS
The CNRS is a major player in fundamental research on a global scale. The CNRS is the only French organization active in all scientific fields. Its unique position as a multi-specialist allows it to bring together different disciplines to address the most important challenges of the contemporary world, in connection with the actors of change.
Create your alert
Don't miss any opportunity to find the job that's right for you. Register for free and receive new vacancies directly in your mailbox.