Missions

The harmful effects of poisonous high-levels of environmental pollutants and intoxication to the central nervous and cardiovascular systems are proven. Surprisingly, insufficient information is available concerning the impact of exposure to pesticide cocktails, as found in agricultural food products. Public relevance grows when considering the effects a cocktail of pollutants could have during development, particularly forming brain and cardiovascular structures.

Activités

We now seek a post-doctoral researcher to test the hypothesis that exposure to pesticide cocktails during development, in compositions and dosages pertinent to environmental contamination and to consumers, results in neuro- and cardio-vascular defects.
The newly hired post-doc will use zebrafish as a model for studying neuro-vascular and cardio-vascular development. In particular the researcher will develop i) a fast and effective in vivo screening of neuro- and cardio-vascular changes induced by environmental pollutants exposure, unveiling the pathological contribution of each of the cocktail components; ii) spatio-temporal 2-Photon reconstructions of the developing neuro- and cardio-vascular structures exploiting ad hoc transgenic zebrafish; iii) identify the genetic signature consequent to the exposure to pollutant cocktails during brain and cardiac development.

Compétences

The ideal candidate will have experience working with zebrafish and be familiar with 2-photon microscopy and basic molecular biology.

Contexte de travail

Institute of Functional Genomics, located in Montpellier, France. Next to INSERM, CNRS, University of Montpellier.
Teams Nicola Marchi (neuro) and Chris Jopling (cardio)

Contraintes et risques

RAS