Researcher in Electrophysiology and Neurobiology of Pain (M/F)
New
- Researcher in FTC
- 12 months
- Doctorate
This offer is available in English version
This offer is open to people with a document recognizing their status as a disabled worker.
Offer at a glance
The Unit
Institut de génomique fonctionnelle
Contract Type
Researcher in FTC
Working hHours
Full Time
Workplace
34094 MONTPELLIER
Contract Duration
12 months
Date of Hire
04/01/2027
Remuneration
Salary ranging from €3,071 to €4,258.87 gross per month, depending on experience
Apply Application Deadline : 23 November 2026 23:59
Job Description
Missions
-The successful candidate will be recruited as part of the ANR project "PROTECT-DN". Their responsibilities will include:
Characterizing the excitability of murine sensory neurons in a model of type 2 diabetic neuropathic pain (induced by a high-fat, high-sugar diet) compared to control animals, by comparing genetic inhibition models of the Cav3.2 calcium channel. Methodological approaches will include ex vivo electrophysiology of sensory fibers and neurons (skin-nerve preparations and patch-clamp recordings), as well as in vivo calcium imaging or extracellular electrophysiology in anesthetized mice (miniscope videofluorimetry or single/multi-unit action potential recordings).
Characterizing the excitability of murine sensory neurons in the same type 2 diabetic neuropathic pain model, comparing animals chronically treated with a T-type calcium channel pharmacological inhibitor currently in clinical development. The methodological approaches will be identical to those outlined in Point 1.
Conducting longitudinal tracking of mechanical and thermal pain sensitivity thresholds in cohorts of mice subjected to the type 2 diabetes model, utilizing a novel automated behavioral analysis platform (RAMalgo system) ensuring unbiased assessment. A development phase will consist of coupling this automated pain evaluation with electrophysiological or videofluorimetric recordings.
Participating in the development of a genetic approach aimed at inducing targeted and progressive degeneration of the sensory neurons most vulnerable to type 2 diabetic neuropathy, and phenotypically characterizing this mouse model in vitro and in vivo.
This work contributes to the validation of a preventive therapeutic strategy for diabetic neuropathic pain, opening concrete perspectives for translating preclinical research into clinical applications.
(12-month contract, renewable)
Activity
Characterize the excitability of peripheral sensory fibers and their modulation by type 2 diabetic pathology (in the high-fat, high-sugar diet model) using ex vivo electrophysiological approaches (skin-nerve technique), in vivo action potential recordings, and videofluorimetry.
Implement an innovative automated platform for behavioral analysis of somatosensation in mice, incorporating cutting-edge technical developments, notably co-recording of electrophysiological signals.
Manage and execute the breeding of transgenic mouse lines required for project needs.
Analyze, interpret, and disseminate experimental data through scientific publications in peer-reviewed international journals.
Your Profil
Skills
Electrophysiological Implementation and Analysis: Mastery of electrophysiological recordings in patch-clamp, skin-nerve preparations, and in vivo single/multi-unit activity for studying cellular excitability, along with data analysis and processing.
Animal Experimentation: Expertise in in vivo animal experimentation within the field of pain and/or other neuroscience domains (neurodegenerative diseases, neurological disorders, metabolic syndrome, etc.). Project Designer certification (Level 1) and surgical competence are mandatory.
Desirable Skills: Proficiency in miniscope imaging, fiber photometry, or in vivo electrophysiology would be a strong asset for the project.
Personal and Interpersonal Skills: Strong ability to perform literature reviews and synthesize findings, solid background in neuroscience and electrophysiology, effective scientific communication skills, autonomy, and proven ability to work as part of a team.
Your Work Environment
The project will be conducted at the Institute of Functional Genomics (IGF) within a research team internationally recognized for its work on T-type calcium channels in somatosensation, chronic pain, and pleasant touch. The recruited researcher will benefit from the multidisciplinary expertise of the team and the Institute, as well as the specialized capabilities of project partners at an institute dedicated to diabetes research, alongside collaborators at UT Dallas (USA).
The IGF is located on the Arnaud de Villeneuve campus, an active participant in the "Objectif Employeur Pro-Vélo" program.
Constraints and risks
No specific constraints or risks.
Application Requirements: Detailed CV, Cover letter tailored to the proposed research project, Contact details for two references
Compensation and benefits
Compensation
Salary ranging from €3,071 to €4,258.87 gross per month, depending on experience
Annual leave and RTT
44 jours
Remote Working practice and compensation
Pratique et indemnisation du TT
Transport
Prise en charge à 75% du coût et forfait mobilité durable jusqu’à 300€
About the offer
| Offer reference | UMR5203-EMMBOU-004 |
|---|---|
| CN Section(s) / Research Area | Molecular and cellular neurobiology, neurophysiology |
| Relevant experience | 5 to 10 years |
About the CNRS
The CNRS is a major player in fundamental research on a global scale. The CNRS is the only French organization active in all scientific fields. Its unique position as a multi-specialist allows it to bring together different disciplines to address the most important challenges of the contemporary world, in connection with the actors of change.
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