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Reference : UMR5175-SYLGAN-004
Workplace : MONTPELLIER
Date of publication : Tuesday, September 01, 2020
Type of Contract : FTC Scientist
Contract Period : 24 months
Expected date of employment : 1 November 2020
Proportion of work : Full time
Remuneration : between 2643€ and 3941€ per month gross salary (depending on previous experience)
Desired level of education : PhD
Experience required : 1 to 4 years
One Postdoc position in computational biology is available at the Centre d'Écologie Fonctionnelle et Évolutive (CEFE) in Montpellier. The post-doc will be working with Sylvain Gandon (http://evolepid.cefe.cnrs.fr/people.php?name=gandon), in collaboration with the Department of infectious diseases at MIVEGEC (Ana Rivero, https://www.mivegec.ird.fr/en/) and the University of Glasgow (Thomas Otto, https://www.gla.ac.uk/researchinstitutes/iii/staff/thomasdanotto/). The position is available from the 1st of January 2020 and is funded by the French Agence Nationale de la Recherche (ANR). This position will come with a competitive postdoctoral-level CNRS salary for two years, with some possibility of extension.
- Genome assembly of different lineages of avian Plasmodium;
- Comparative genomics of different avian Plasmodium lineages;
- Detection of recombination events among different Plasmodium lineages;
- Detection of selection in different Plasmodium genes;
- Analysis of the evolution of multi-copy genes in relation to specialisation to different avian host species;
- Demographic inference (i.e. epidemiology of different avian malaria lineages) from genomic data.
- Bioinformatics and genome assembly;
- Comparative genomics;
- Population genetics and detection of selection;
- Dmographic inference from genomics data;
- This project implies collaboration with other reserachers in France (Montpellier) and abroad (Scotland) and will imply short visits;
- Ability to work independently.
Recent molecular protocols for detecting and characterizing avian malaria lineages in the field are providing an ever-growing picture of the prevalence, distribution, host range, and diversity hotspots of avian malaria across the world. The unparalleled genetic diversity uncovered rivals anything that has been found in other vertebrate malarias and seems to be matched by an equally rich phenotypic diversity, providing endless opportunities for exploring the selective pressures under which hosts and parasites evolve.
We have recently developed new ways to obtain whole genome sequences of the avian Plasmodium lineages circulating in multiple hosts. The purpose of the project is to explore the genomic basis of avian Plasmodium adaptations to multiple host species. The comparative genomics of multiple lineages with different host ranges will allow us to explore the underlying genetic determinism of generalism/specialism in avian malaria. The sequences will also be used to clarify the species status and resolve the phylogenic relationship between the different lineages.
Constraints and risks
Nothing to report
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