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Reference : UMR5174-FRARIC-002
Workplace : TOULOUSE
Date of publication : Monday, November 09, 2020
Type of Contract : FTC Scientist
Contract Period : 24 months
Expected date of employment : 1 December 2020
Proportion of work : Full time
Remuneration : Between 2648 and 3054 euros gross monthly salary depending of experience
Desired level of education : PhD
Experience required : 1 to 4 years
Up to 8% of the human genome comes from extinct hominins and yet the biological role of this inheritance is still poorly understood. Our group uses cutting-edge functional genomics approaches to characterize the role of Denisovan introgressions in the evolutionary history of Papua New Guinean populations. The candidate will identify bioinformatically archaic genetic loci of functional importance in Papuan genomes and validate their biological role ex vivo. This project is part of a wider program focusing on the evolutionary history of Papua New Guinea (https://papuanpast.hypotheses.org/).
Main tasks :
- To perform the bioinformatic analyses of the genomic (Xten, 30X) and transcriptomic data (RNA-Seq) produced during the project and to construct comparative datasets
- To make the statistical analyses of the genomic data, including population genetic analyses and quantitative-traits loci analyses
-To perform iPSC protocol from PBMC and to generate iPSC-derived macrophages
- To interpret and summarize the results in peer-reviewed publications
-To animate scientific discussion in the team
-To organize monthly visioconferences with international collaborators
-To train master students
-PhD degree in human population genetics, functional genomics, bioinformatics or related fields
- Solid background in computational and statistical skills with expertise in functional genomics analyses
- Proficiency in spoken and written English
- Ability to work in a team and in an interdisciplinary environment
- Less 2 years experience
The laboratory of Evolution and Biological Diversity (UMR5174; https://edb.cnrs.fr) is internationally renowned for its research in the interaction between the environment and the biodiversity using genetic tools. Several projects are developed in diverse animal phyla, including humans, especially in tropical areas. The candidate will have the opportunity to work in a stimulating multidisciplinary environment composed by researchers from different fields of research. The candidate will intensively collaborate with our international collaborators from Australia, Estonia and Papua New Guinea. CNRS and the UMR5174 is an equal opportunity employer.
Constraints and risks
The project involves human DNA and human cells which implies specific safety measures. The candidate will be trained by lab managers to respect the safety guidelines.
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