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Reference : UMR5169-MARGIU1-005
Workplace : TOULOUSE
Date of publication : Thursday, October 01, 2020
Type of Contract : FTC Technical / Administrative
Contract Period : 36 months
Expected date of employment : 1 January 2021
Proportion of work : Full time
Remuneration : Between 2437 and 2616 euros gross monthly according to experience
Desired level of education : 5-year university degree
Experience required : Indifferent
The Research Engineer will participate in the establishment and maintenance of a multiphoton microscope for the realization of the ERC Advanced Grant project 'COGNIBRAINS' whose aim is to study and identify the nervous mechanisms involved in the capacities of visual learning (simple and complex). The experiments will be carried out on bees, placed in a virtual reality device. The Research Engineer will be 100% assigned to carrying out the project and will be involved in performing experiments and assisting users on this imaging system. He will design and implement devices adapted to the successful completion of acquisitions in order to obtain reliable and analyzable data of brain activity in vivo. The work will be carried out in close relation with a post-doctoral fellow recruited for the same project.
Installation, maintenance and support of experiences combining behavioral analysis with visual learning of bees, in a virtual reality device. He / she will be involved in the installation and coupling of this device with the bi-photon microscope and will be responsible for obtaining the data for the analysis of the activity of the nervous circuits underlying cognitive tasks. He / she will use neural tagging methods and analyze and process the imaging data.
Proven experience in multiphoton imaging.
Signal processing and analysis of observed calcium signals. To know how to implement and develop markings of neurons suitable for observation in bi-photon microscopy. Statistical processing of imaging data. Realization of experiments in support of the post-doctoral researcher of the project. Notions of Unity programming would be a plus (virtual reality programming)
Hourly conditions established at 7.42am per day, 5 days per week. The IR will also participate in the periodic meetings of the members of the ERC consortium participating in the project (three postdoctoral fellows and a study engineer) as well as in regular meetings, congresses, seminars, etc. in which the reception team participates.
The IR will be responsible for a multi-photon microscope (metrological control, after-sales service, etc.) and must actively contribute to obtaining data on brain activity in bees placed in this device. He / she will also have an office and access to IT facilities allowing him / her to successfully complete his / her work.
Constraints and risks
Faced with the possible risk of bee stings, people with allergies should refrain.
Bigger brains do not always exhibit more complex behavior. Take, for example, bees and other social insects that have miniature brains. Despite the tiny size of their brains, they are capable of great feats like categorizing and learning concepts, and even numbers. All this with only 950,000 neurons (the human brain contains about 100 billion). The EU-funded COGNIBRAINS project will study bees to discover which minimal circuits mediate the most ordered forms of cognitive processes in the brain. It will combine recordings of bee behavior learning nonlinear discrimination and relational rules. The overall objective of this project is to provide the first full characterization of the mechanisms underlying cognitive faculties in a miniature brain.
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