Missions

The postdoctoral researcher will work on characterizing the role of myelin in the development of glioblastomas. The postdoc will use in vitro approaches to culture patient-derived cells with oligodendrocytes and will also be required to carry out or assist with in vivo experiments. This work will be conducted as part of a competitive grant obtained by a consortium bringing together French teams with complementary neuro-oncology models, tools, and expertise, including cancer cell metabolism and computational biology. This project is also part of an international collaboration with a laboratory at the DKFZ in Heidelberg, Germany.

Activities

Main activities
• Establishing the technique for culturing murine oligodendrocytes and co-culturing them with glioblastoma cells.
• Carrying out experimental assays required for the project (genetic and pharmacological manipulation of human cancer cells, cell biology experiments, biochemistry, metabolic profiling, measurement of metabolic or electric activities via probes or MEA system, and in vitro imaging using confocal microscopy).
• Animal experiment to decipher the most important lipids during glioblastoma invasion.
• Monitoring the scientific literature relevant to the project.
• Presenting results at weekly laboratory meetings and at national and international scientific meetings.

Secondary activities
• Interacting with other team members and collaborators.
• Participating in in vivo experiments (access to immunodeficient animals and neurosurgery).
• Taking part in the laboratory's collective activities (e.g., meetings, seminars).

Skills

Main skills:
• Expertise in neuroscience, cellular and molecular biology, and metabolic analyses.
• Knowledge of neuro-oncology would be an asset.
• Familiarity with the functioning of cerebral metabolic systems or glioblastoma biology will be appreciated.
• Language skills: proficiency in spoken and written English is essential in the international group.

Skills:
• Strong proficiency in human cell culture techniques, microscopy, and solid knowledge of metabolic fluxes, metabolomic and transcriptomic analyses.
• Ability to quickly adapt to new methodologies.
• Proficiency in using computer tools and software dedicated to data processing.

Personal qualities:
• The postdoctoral researcher must be motivated, rigorous, well-organized, and able to work independently.

Additional training opportunities aimed at enriching the postdoctoral researcher's knowledge may be offered during the fixed-term contract.

Work Context

This position is part of the INCA PLBIO project, which brings together experts in neuro-oncology, lipidomics analysis, and bioinformatics to understand the functional role of lipids in the development of glioblastomas.
The project is embedded within these activities, ensuring a stimulating scientific environment at the interface of cancer research, neuroscience, and bioinformatics.
The postdoctoral researcher will join the Glioblastoma Metabolism team at IBGC (CNRS, Bordeaux), led by Dr. Thomas Daubon, and will work in close collaboration with the consortium's partners, including the teams of Dr. Lucie Brisson (Bordeaux), Dr. Justine Bertrand-Michel (Toulouse), and Dr. Marie Beurton-Aimar (Bordeaux).

Constraints and risks

Schedules will be made within regulatory working hours. The postdoctoral scientist must go to several sites to perform the experiments (vehicle needed). The candidate will work on immunocompetent mouse models, with patient samples. The candidate will work on immunodeficient and immunocompetent mouse models, with patient samples. However, all health risks are perfectly controlled by the team. The candidate will be trained in the potential risks associated with the project by the manager upon arrival at the laboratory. He / She will also receive training for new entrants provided by the Prevention Assistants of the Unit.