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Reference : UMR5089-JERNIG-005
Workplace : TOULOUSE
Date of publication : Monday, May 03, 2021
Type of Contract : FTC Scientist
Contract Period : 12 months
Expected date of employment : 1 September 2021
Proportion of work : Full time
Remuneration : The gross salary will be from 2648 to 3054 € per month, depending on the experience.
Desired level of education : PhD
Experience required : 1 to 4 years
Tuberculosis is one of the top ten causes of death worldwide and the leading cause of death from a single infectious agent. Mycobacterium tuberculosis (Mtb), its causative agent, is a highly successful intracellular pathogen that has adapted to subvert the function of phagocytic cells. To this end, it uses different strategies, many of which involve the highly abundant, structurally diverse, and potently immunomodulatory glycolipids expressed at its cell envelope. One of our team objectives is to decipher the role and structure-function relationships of glycolipids in the innate immune recognition of Mtb. We and others have shown that Mtb glycolipids are recognized by several PRRs, including TLR2 and the C-type lectins DC-SIGN, Mincle, or Dectin-2. However, the binding mode, the functional consequences in host cells of glycolipid/PRR interaction and the repertoire of PRRs involved in Mtb glycolipid recognition remain to be fully uncovered. Hence, as part of this research theme, the recruited candidate will address these different facets. More specifically, his/her work will aim at identifying and characterizing new glycolipid/PRR interactions in the context of Mtb infection, delineating the signaling pathways triggered, and determining their contribution to innate immune response and to Mtb virulence in macrophages and in mice.
The recruited candidate will aim at identifying and characterizing new glycolipid/PRR interactions in the context of Mtb infection, delineating the signaling pathways triggered, and determining their contribution to innate immune response and to Mtb virulence in macrophages and in mice.
- The minimum qualification: immunology, cell biology or molecular biology.
- The ideal candidate for this position should be highly motivated, have excellent verbal and written communication skills as well as strong leadership, independent thinking and problem solving skills.
- Previous experience in the fields of lipids, glycoconjugates or innate immunity will be a plus.
- Candidates must assume a leading role in a team involving several graduate and PhD students, and have the ability to work in a multidisciplinary team.
- Candidates must have proven track record of publishing peer reviewed papers, excellent organizational skills and attention to detail; they must possess a strong work ethic.
The IPBS provides an excellent scientific environment and is fully equipped with state-of-the art equipment needed to perform the project, including BSL2, BSL3, imaging, flow cytometry, and proteomics facilities.
Constraints and risks
The recruited candidate will work in BSL2 and BSL3.
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