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Portail > Offres > Offre UMR5089-JERNIG-004 - H/F OFFRE DE POSTDOCTORAT: ANALYSE STRUCTURE/FUNCTION DES GLYCOLIPIDES MYCOBACTERIENS

H/F POST-DOCTORAL POSITION IN STRUCTURE/FUNCTION ANALYSIS OF MYCOBACTERIAL GLYCOLIPIDS

This offer is available in the following languages:
Français - Anglais

Date Limite Candidature : lundi 17 mai 2021

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General information

Reference : UMR5089-JERNIG-004
Workplace : TOULOUSE
Date of publication : Monday, April 26, 2021
Type of Contract : FTC Scientist
Contract Period : 12 months
Expected date of employment : 1 September 2021
Proportion of work : Full time
Remuneration : From 2648 et 3054 € gross salary per month depending on experience.
Desired level of education : PhD
Experience required : 1 to 4 years

Missions

Tuberculosis is one of the top ten causes of death worldwide and the leading cause of death from a single infectious agent. Mycobacterium tuberculosis (Mtb), its causative agent, is a highly successful intracellular pathogen that has adapted to subvert the function of phagocytic cells. To this end, it uses different strategies, many of which involve the highly abundant, structurally diverse, and potently immunomodulatory glycolipids expressed at its cell envelope. Although key strategies have been identified, the underlying molecular mechanisms remain to be fully uncovered. Hence, one of our team objective is to decipher at the molecular level the role and structure-function relationships of glycolipids in the innate immune recognition of Mtb.
We have recently identified the signature of yet unknown lipids produced by virulent Mtb strains, but not by the attenuated BCG strain. These Mtb-specific lipids are likely to be key immunomodulatory molecules.
The project of the recruited candidate will be to purify and perform the structural characterization of these newly identified glycolipids. He/she will also be involved in determining their ability to modulate innate immune response and to contribute to Mtb virulence in macrophages and/or in mice.

Activities

The project of the recruited candidate will be to purify and perform the structural characterization of these newly identified glycolipids. He/she will also be involved in determining their ability to modulate innate immune response and to contribute to Mtb virulence in macrophages and/or in mice.

Skills

- The minimum qualification: PhD degree in biochemistry, structural biochemistry, analytical chemistry, or microbiology.
- The ideal candidate for this position should be highly motivated, have excellent verbal and written communication skills, leadership skills, and independent thinking and problem solving skills.
- Previous experience in the fields of lipids or glycoconjugates will be a plus.
- Candidates must assume a leading role in a team involving several graduate and PhD students, and have the ability to work in a multidisciplinary team.
- Candidates must have proven track record of publishing peer reviewed papers, excellent organizational skills and attention to detail; they must possess a strong work ethic.

Work Context

The IPBS provides an excellent scientific environment and is fully equipped with state-of-the art equipment needed to perform the project, including chromatography, NMR, MS, imaging, BSL2 and BSL3 facilities.

Constraints and risks

The candidate may have to work in a BSL3.

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