Missions

The Postdoctoral researcher will work as part of an inter-team collaboration: the "DDR" team at the Institute of Pharmacology and Structural Biology (IPBS) and the "New Antimalarial Molecules and Pharmacological Approaches" team at the Laboratory of Chemistry of Coordination (LCC), both located on the same CNRS campus.

Activities

The proposed project focuses on the molecular characterization of the mechanisms underlying the antiplasmodial activity of a chemical compound through:
Evaluation of the cytotoxic activity of small molecules using viability assays
Selection of a resistant parasite strain through drug pressure
Analysis of the effects of molecules on nucleic acids using molecular approaches: qPCR, RTqPCR
Analysis of the effects of compounds on the integrity of parasite organelles using Super resolution Microscopy.

Skills

PhD in Biology; Prerequisites: experience in parasitology, parasitic culture of P. falciparum in an L2+ laboratory. Experimental skills in: cell culture, Western blot, molecular biology, DNA/RNA extraction, qPCR, immunofluorescence, fluorescence microscopy imaging. Organizational skills, scientific rigor, and adherence to protocols. Ability to organize work independently and methodically, in coordination with other team members. Ability to integrate into two academic research teams, respecting schedules and the work of other team members. Ability to maintain a lab notebook, format results, and present them.

Work Context

The work is carried out as part of an inter-team collaboration, with both teams located on the same site, in the same building.

Constraints and risks

Work in a confined L2+ laboratory. Weekend work may be required depending on experimental constraints.