Missions

The postdoctoral researcher will devote their time to identifying microproteins in biological serum samples from patients with pancreatic cancer at different stages. This involves, in particular, developing specific microprotein extraction methods coupled with mass spectrometry analyses. He/she will participate in studies to characterise the function of these microproteins in collaboration with Yvan Martineau's team at the CRCT in Toulouse.

Activités

- Enrichment of microproteins from serum. - Analysis of samples produced by mass spectrometry. - Design of synthetic peptide libraries for validation of mass spectrometry data.

Compétences

- Microprotein enrichment (prerequisite). - Proteomics and mass spectrometry for microprotein analysis (prerequisite). - Bioinformatic analysis dedicated to the identification and quantification of microproteins by mass spectrometry (prerequisite). - Protein assay (basic concepts, internal training available).

Contexte de travail

The Institute of Pharmacology and Structural Biology (IPBS) is a joint research unit of the CNRS and the University of Toulouse located on the Rangueil site south of Toulouse. The main objective of the IPBS is the identification, characterisation and exploitation of new therapeutic targets in the fields of cancer, infection and inflammation. The project focuses on pancreatic cancer. More specifically, it consists of a study aimed at characterising microproteins in this cancer in order to assess their potential as new therapeutic targets or new early biomarkers of the disease. This ambitious project is based on the collaboration of two teams: the 'Proteomics and Biomolecule Mass Spectrometry' team (Eq. O. Schiltz) at IPBS and the 'MICROPANC' team (Eq. C. Bousquet) at CRCT. This position is specifically part of the studies conducted by B. Fabre (O. Schlitz team, IPBS) and Y. Martineau (C. Bousquet team, CRCT) and requires the candidate to have good communication skills.