Missions

We are searching a postdoctoral researcher who works with us on the ANR project entitled “AROSE - Assessing the functions of histone ADP-ribosylation during DNA repair”.

Activités

The aim of the project is to study the effect of histone ADP-ribosylation on chromatin organization by in vitro approaches using reconstituted chromatin. The recruited person will purify the proteins required for in vitro chromatin assembly and histone ADP-ribosylation. Analyses are mainly carried out using fluorescence microscopy and transmission electron microscopy methods on reconstituted chromatin.

Compétences

- hold a PhD in biochemistry, biophysics or molecular biology
- have practical experience in one of these fields, ideally with chromatin, phase separation, single-molecule microscopy and/or electron microscopy
- have knowledge in data analysis with R, Python or similar
- have a strong motivation to develop skills in quantitative microscopy and interdisciplinary research
- be independent, well-organized, reliable, and have the ability and interest to work in a team
- speak English (the working language of the team is English)

Contexte de travail

The "Mechanism of chromatin patterning" team is an international, interdisciplinary team belonging to the MCD unit within the Center for Integrative Biology (CBI) in Toulouse, which benefits from all the technical resources, equipment and technical core facilities required to carry out the project.