Faites connaître cette offre !
Reference : UMR5063-YUNWON-001
Workplace : GRENOBLE
Date of publication : Wednesday, January 12, 2022
Type of Contract : FTC Scientist
Contract Period : 12 months
Expected date of employment : 1 March 2022
Proportion of work : Full time
Remuneration : Starting from 2663,79 euro according experiences
Desired level of education : PhD
Experience required : 1 to 4 years
Anti-inflammatory drugs are used for many indications such as arthritis, respiratory diseases, multiple sclerosis, psoriasis, and inflammatory bowel disease. Current anti-inflammatory drugs can cause serious side effects such as gastrointestinal, cardiovascular and renal disorders, limiting their therapeutic efficacy and leading to numerous side effects.
The DPM team, in collaboration with a team from the Institute for Advanced Biosciences (IAB) in Grenoble and with the Inovotion company, is developing a new family of anti-inflammatory compounds devoid of in vitro toxic effects at this stage. The project is now moving to in vivo model stage, and the objective is to optimize the pharmacokinetic characteristics of the best compounds. This development is greatly facilitated by the synthetic approach which is based on the use of a new organocatalysed multicomponent reaction controlling both the diversification and the enantiopurity of the products obtained. New approaches involving the implementation of bio-compatible click reactions will be applied to improve therapeutic effects and to elucidate mechanisms of action.
- Organic synthesis
- Study of click reaction kinetics
- Optimization of pharmacokinetic properties
The candidate must have a strong background in organic synthesis. Additional experience in the use of click chemistry in the living environment would be appreciated. The successful candidate will be autonomous, rigorous, able to work in a team and to interact with the numerous partners involved in this project.
The work is part of a collaborative work between two academic teams (DPM and IBS) and a company (Inovotion) to develop new anti-inflammatory drugs with low toxicity. The work will be carried out at the Department of Molecular Pharmacochemistry (DPM) which is a joint CNRS/University of Grenoble Alpes (UGA) unit. The Unit is attached to the UFR of Pharmacy and is interested in the whole value chain in pharmaceutical science and towards the needs of the hospital. The staff is grouped in two teams, COMET and NOVA. The work will be done within the COMET team, which is interested in the design of active ingredients, the synthesis of compounds with high diversity/complexity, the development of molecular tools for the detection of biomolecules and the use of click reactions in living environments.
We talk about it on Twitter!