Informations générales
Intitulé de l'offre : Engineering position on spatial genomics (M/F) (H/F)
Référence : UMR5048-FLOLEP-117
Nombre de Postes : 2
Lieu de travail : MONTPELLIER
Date de publication : vendredi 17 octobre 2025
Type de contrat : IT en contrat CDD
Durée du contrat : 12 mois
Date d'embauche prévue : 1 janvier 2026
Quotité de travail : Complet
Rémunération : Between €2521 and €2688 gross per month according to experience
Niveau d'études souhaité : BAC+3/4
Expérience souhaitée : 1 à 4 années
BAP : A - Sciences du vivant, de la terre et de l'environnement
Emploi type : Ingenieure ou ingenieur en experimentation et instrumentation biologiques
Missions
We are looking for highly motivated candidates to fill two engineer positions:
- (project 1) use spatial genomics to investigate the mechanisms driving chromatin organization during meiosis in mice, and
- (project 2) develop imaging-based spatial multi-omics to visualize epigenetic marks and 3D chromatin organization in Drosophila, mouse and human samples.
Activités
Candidates for project 1 will be in charge of:
- amplifying oligopaint libraries,
- performing DNA-FISH,
- preparing chromosome spreads/squash from spermatocytes, and
- acquiring and analyzing spatial genomics datasets.
Candidates for project 2 will be in charge of:
- designing and validating spatial multi-omics strategies to image epigenetic marks in cancer models.
Compétences
Candidates for project 1 will have expertise in microscopy and/or molecular biology.
Candidates for project 2 will have experience in molecular biology and sequencing-based technologies.
Candidates are expected to express a strong interest in working at the interface between biology, bioinformatics and physics. Work will involve active collaborations with Thomas Robert (CBS, Montpellier), Cedric Maurange (IBDM Marseille) and Celine Vallot (Institut Curie).
Positions are funded by the French National Research Agency-ANR (Comore) and the PEPR Cell-ID.
Contexte de travail
The Center for Structural Biology (CBS) carries out research at the forefront of structural biology and biophysics as a means to reveal the fundamental physical mechanisms underlying biological activity and its regulation. The CBS is located at the heart of a world-class research campus in Biology in the vibrant city of Montpellier in the French Riviera.
Our interdisciplinary group is interested in understanding the mechanisms of DNA organization and remodeling by building state-of-the-art microscopes, and image analysis tools. We have recently developed a novel spatial genomics methodology (Hi-M) to acquire tens/hundreds color images.
Le poste se situe dans un secteur relevant de la protection du potentiel scientifique et technique (PPST), et nécessite donc, conformément à la réglementation, que votre arrivée soit autorisée par l'autorité compétente du MESR.
Contraintes et risques
Initial contract of 1 year duration with the possibility of renewal.
Applicants should submit their CV with references
No minimum experience required.