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Portail > Offres > Offre UMR5048-FLOLEP-036 - Post-doctorat en modélisation moléculaire des condensats cellulaires H/F

Post-doctoral position in molecular modeling of cellular condensates

This offer is available in the following languages:
Français - Anglais

Date Limite Candidature : vendredi 12 août 2022

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General information

Reference : UMR5048-FLOLEP-036
Workplace : MONTPELLIER
Date of publication : Friday, July 22, 2022
Type of Contract : FTC Scientist
Contract Period : 12 months
Expected date of employment : 1 November 2022
Proportion of work : Full time
Remuneration : Between €2739 and €3869 gross per month according to experience
Desired level of education : PhD
Experience required : 1 to 4 years

Missions

Investigate the role of the phase separation of prion-like domains in plant environmental response

Activities

The candidate will develop and apply multi-scale modeling strategies encompassing atomistic and coarse grained molecular simulations and rate models for translating the results of our experimental partners into a quantitative, comprehensive picture and for exploring the general thermodynamic principles underlying the assembly and regulation of cellular condensates.

Skills

We are looking for motivated and ambitious candidates with a strong background in physical sciences (e.g. physics, chemistry, or engineering) and a keen interest for studying biological systems. Solid programming/scripting skills and excellent teamwork attitude are required. Substantial previous experience with (bio)molecular simulations, supported by publication record, is expected.

Work Context

The position is funded by the French National research Agency (ANR) within the Prospero project.

This collaborative project aims at combining a variety of experimental techniques in biophysics and molecular/cellular biology with theoretical modelling for characterizing the functional, structural and mechanical properties of cellular condensates. Biomolecular condensates arising from the phase separation of proteins and/or nucleic acids are presently recognized to play a key role in organizing cellular environment and they are attracting a huge and ever-increasing attention in disparate fields ranging from soft-matter physics to physiology.

The goal of the Prospero project aims at investigating the role of the phase separation of prion-like domains in plant environmental response and it relies on a French-German consortium involving C. Zubieta (IRIG, Grenoble), L. Costa (CBS, Montpellier), P. Wigge (IGZ, Berlin), and Y. Stahl (U. Düsseldorf) .

WORKING ENVIRONMENT:
The CBS Montpellier (INSERM U1054, CNRS 5048) is a research center at the forefront of biophysics and structural biology. CBS research staff and infrastructure cover a wide variety of techniques including X-ray crystallography, cryoEM, advanced fluorescence and super-resolution microscopies, single-molecule manipulation, molecular and cell biology, and high-performance computing. Montpellier is a major scientific hub for life sciences and its science drive, the beauty of the region, its high quality of life make it an ideal destination for scientists from all over the world.

Constraints and risks

The initial contract will be for a 12 months duration. It can be renewed for 12 months to make a total of 24 months. The position is available starting from autumn 2022.

Additional Information

Please submit your application, including: i) a cover letter (explaining background and motivation), ii) a CV with a publication list (if applicable) iii) contact details of 2 referees and iv) all relevant diplomas, including grades.

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